کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10869850 1073974 2015 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Architectural proteins, transcription, and the three-dimensional organization of the genome
ترجمه فارسی عنوان
پروتئین های معماری، رونویسی، و سازمان سه بعدی ژنوم
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک دانش گیاه شناسی
چکیده انگلیسی
Architectural proteins mediate interactions between distant sequences in the genome. Two well-characterized functions of architectural protein interactions include the tethering of enhancers to promoters and bringing together Polycomb-containing sites to facilitate silencing. The nature of which sequences interact genome-wide appears to be determined by the orientation of the architectural protein binding sites as well as the number and identity of architectural proteins present. Ultimately, long range chromatin interactions result in the formation of loops within the chromatin fiber. In this review, we discuss data suggesting that architectural proteins mediate long range chromatin interactions that both facilitate and hinder neighboring interactions, compartmentalizing the genome into regions of highly interacting chromatin domains.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: FEBS Letters - Volume 589, Issue 20, Part A, 7 October 2015, Pages 2923-2930
نویسندگان
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