کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10870013 1073987 2014 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Zinc finger protein ZBTB20 promotes cell proliferation in non-small cell lung cancer through repression of FoxO1
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک دانش گیاه شناسی
پیش نمایش صفحه اول مقاله
Zinc finger protein ZBTB20 promotes cell proliferation in non-small cell lung cancer through repression of FoxO1
چکیده انگلیسی
In the present study, we found that ZBTB20, a member of the POK (POZ and Krüppel) family of transcriptional repressors, was significantly up-regulated in lung cancer tissues, compared with adjacent normal tissues. Our in vitro studies further found that ZBTB20 overexpression promoted, while its inhibition using small interfering RNA suppressed cell proliferation. Consistently, key regulators in cell-cycle progression, such as Cyclin D1, Cyclin E, P21 and P27, were also regulated by ZBTB20. At the molecular level, we further revealed that FoxO1, a tumor suppressor in multiple human cancers, was transcriptionally repressed by ZBTB20. Therefore, our results highlight an important role for ZBTB20 in controlling NSCLC development, which might be helpful to identify potential therapeutic targets for its treatment.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: FEBS Letters - Volume 588, Issue 24, 20 December 2014, Pages 4536-4542
نویسندگان
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