کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10870275 | 1073996 | 2015 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
VCP/Cdc48 rescues the growth defect of a GPI10 mutant in yeast
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم کشاورزی و بیولوژیک
دانش گیاه شناسی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: VCP/Cdc48 rescues the growth defect of a GPI10 mutant in yeast VCP/Cdc48 rescues the growth defect of a GPI10 mutant in yeast](/preview/png/10870275.png)
چکیده انگلیسی
We identified a yeast mutant with temperature-sensitive growth defects that were rescued by VCP expression. The mutation occurred in GPI10, which encodes a mannosyl transferase for glycosylphosphatidylinositol anchor formation in the endoplasmic reticulum, and caused a Gly469Glu substitution in Gpi10. The mutant exhibited increased unfolded protein response, which was partially rescued by VCP or Cdc48, and showed sensitivity against cell-wall stressors, which were not rescued by VCP. These results suggest a potential link between VCP/Cdc48 and Gpi10 functions in the control of cell growth.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: FEBS Letters - Volume 589, Issue 5, 27 February 2015, Pages 576-580
Journal: FEBS Letters - Volume 589, Issue 5, 27 February 2015, Pages 576-580
نویسندگان
Yohei Ohnuma, Takahiro Takata, Junko Kawawaki, Kunihiko Yasuda, Keiji Tanaka, Yoko Kimura, Akira Kakizuka,