کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10870365 1073999 2014 33 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Nucleases in homologous recombination as targets for cancer therapy
ترجمه فارسی عنوان
نوکلئوزها در نوترکیب همولوگ مانند اهداف درمان سرطان
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک دانش گیاه شناسی
چکیده انگلیسی
Genomic DNA is constantly challenged from endogenous as well as exogenous sources. The DNA damage response (DDR) mechanism has evolved to combat these challenges and ensure genomic integrity. In this review, we will focus on repair of DNA double-strand breaks (DSB) by homologous recombination and the role of several nucleases and other recombination factors as suitable targets for cancer therapy. Their inactivation as well as overexpression have been shown to sensitize cancer cells by increasing toxicity to DNA-damaging agents and radiation or to be responsible for resistance of cancer cells. These factors can also be used in targeted cancer therapy by taking advantage of specific genetic abnormalities of cancer cells that are not present in normal cells and that result in cancer cell lethality.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: FEBS Letters - Volume 588, Issue 15, 1 August 2014, Pages 2446-2456
نویسندگان
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