کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10870817 | 1074021 | 2013 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Caspase-mediated cleavage and DNase activity of the translation initiation factor 3, subunit G (eIF3g)
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم کشاورزی و بیولوژیک
دانش گیاه شناسی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Eukaryotic translation initiation factor 3 is composed of 13 subunits (eIF3a through eIF3m) and plays an essential role in translation. During apoptosis, several caspases rapidly down-regulate protein synthesis by cleaving eIF4G, -4B, -3j, and -2α. In this study, we found that the activation of caspases by cisplatin in T24 cells induces the cleavage of subunit G of the eIF3 complex (eIF3g). The cleavage site (SLRD220G) was identified, and we found that the cleaved N-terminus was translocated to the nucleus, activating caspase-3, and that it also showed a strong DNase activity. These data demonstrate the important roles of eIF3g in the translation initiation machinery and in DNA degradation during apoptosis.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: FEBS Letters - Volume 587, Issue 22, 15 November 2013, Pages 3668-3674
Journal: FEBS Letters - Volume 587, Issue 22, 15 November 2013, Pages 3668-3674
نویسندگان
Jong-Tae Kim, Seon-Jin Lee, Bo-Yeon Kim, Chul-Ho Lee, Young Il Yeom, Yong-Kyung Choe, Do-Young Yoon, Suhn-Kee Chae, Jung Woo Kim, Young Yang, Jong-Seok Lim, Hee Gu Lee,