HDAC6 promotes hepatocellular carcinoma progression by inhibiting P53 transcriptional activity

► Up-regulation of HDAC6 is a frequent event in HCC tissues or cells. ► Identification of HDAC6 as a transcriptional target of NF-κB. ► HDAC6 promotes HCC cell proliferation. ► HDAC6 Physically Interacts with Hdm2 and p53.