An autoregulatory feedback loop between Mdm2 and SHP that fine tunes Mdm2 and SHP stability

► SHP drastically stabilizes Mdm2 protein by abrogating Mdm2 self-ubiquitination. ► Mdm2 causes SHP degradation under p53-deficient conditions. ► SHP K170 residue is critical for SHP and Mdm2 interaction and cross-regulation.