کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10871952 | 1074094 | 2011 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Lactate downregulates the glycolytic enzymes hexokinase and phosphofructokinase in diverse tissues from mice
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم کشاورزی و بیولوژیک
دانش گیاه شناسی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Lactate downregulates the glycolytic enzymes hexokinase and phosphofructokinase in diverse tissues from mice Lactate downregulates the glycolytic enzymes hexokinase and phosphofructokinase in diverse tissues from mice](/preview/png/10871952.png)
چکیده انگلیسی
We examined the effects of lactate on the enzymatic activity of hexokinase (HK), phosphofructokinase (PFK) and pyruvate kinase (PK) in various mouse tissues. Our results showed that lactate inhibited PFK activity in all the analyzed tissues. This inhibitory effect was observed in skeletal muscle even in the presence of insulin. Lactate directly inhibited the phosphorylation of PFK tyrosine residues in skeletal muscle, an important mechanism of the enzyme activation. Moreover, lactate indirectly inhibited HK activity, which resulted from its cellular redistribution, here attributed to alterations of HK structure. PK activity was not affected by lactate. The activity of HK and PFK is directly related to glucose metabolism. Thus, it is conceivable that lactate exposure can induce inhibition of glucose consumption in tissues.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: FEBS Letters - Volume 585, Issue 1, 3 January 2011, Pages 92-98
Journal: FEBS Letters - Volume 585, Issue 1, 3 January 2011, Pages 92-98
نویسندگان
Tiago C. Leite, Raquel G. Coelho, Daniel Da Silva, Wagner S. Coelho, Monica M. Marinho-Carvalho, Mauro Sola-Penna,