microRNA-1274a, a modulator of sorafenib induced a disintegrin and metalloproteinase 9 (ADAM9) down-regulation in hepatocellular carcinoma

► We postulated that microRNAs (miRNA) might be involved in HCC target-chemotherapy with sorafenib. ► MiRNA profile of HepG2 was evaluated after treatment of vehicle or sorafenib and 14 miRNAs showed alterated expression. ► MiR-1274a, which is up-regulated by sorafenib, could significantly repress expression of ADAM9 in HCC cells.