کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10872195 1074110 2009 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
A conserved sequence in caveolin-1 is both necessary and sufficient for caveolin polarity and cell directional migration
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک دانش گیاه شناسی
پیش نمایش صفحه اول مقاله
A conserved sequence in caveolin-1 is both necessary and sufficient for caveolin polarity and cell directional migration
چکیده انگلیسی
Caveolin-1 (Cav-1) plays an important role in the organization of signaling molecules involved in a variety of signaling pathways, including those mediating cell motility. Here we show that amino acids K47-K57 of Cav-1 are a highly conserved sequence in Cav-1 and Cav-3 proteins, and that expression of either K47-K57 deletion Cav-1 mutant or wild-type Cav-2 that lacks this sequence exhibits a non-polarized distribution pattern. Expression of K47-K57 in Cav-2 leads to Cav-2 polarity, suggesting that expression of K47-K57 is sufficient to direct caveolin polarity. Importantly, we show that expression of this sequence is both necessary and sufficient to promote cell directional migration. Thus, our results support the conclusion that Cav-1 polarity is critical for cell directional migration.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: FEBS Letters - Volume 583, Issue 22, 19 November 2009, Pages 3681-3689
نویسندگان
, , , , , ,