کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10872255 | 1074111 | 2010 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Curcumin inhibits hepatitis B virus via down-regulation of the metabolic coactivator PGC-1α
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم کشاورزی و بیولوژیک
دانش گیاه شناسی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Curcumin inhibits hepatitis B virus via down-regulation of the metabolic coactivator PGC-1α Curcumin inhibits hepatitis B virus via down-regulation of the metabolic coactivator PGC-1α](/preview/png/10872255.png)
چکیده انگلیسی
Hepatitis B virus (HBV) infects the liver and uses its cell host for gene expression and propagation. Therefore, targeting host factors essential for HBV gene expression is a potential anti-viral strategy. Here we show that treating HBV expressing cells with the natural phenolic compound curcumin inhibits HBV gene expression and replication. This inhibition is mediated via down-regulation of PGC-1α, a starvation-induced protein that initiates the gluconeogenesis cascade and that has been shown to robustly coactivate HBV transcription. We suggest curcumin as a host targeted therapy for HBV infection that may complement current virus-specific therapies.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: FEBS Letters - Volume 584, Issue 11, 3 June 2010, Pages 2485-2490
Journal: FEBS Letters - Volume 584, Issue 11, 3 June 2010, Pages 2485-2490
نویسندگان
Maya Mouler Rechtman, Ofir Har-Noy, Iddo Bar-Yishay, Sigal Fishman, Yaarit Adamovich, Yosef Shaul, Zamir Halpern, Amir Shlomai,