کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10872338 1074115 2011 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Expression of S100A8/A9 in HaCaT keratinocytes alters the rate of cell proliferation and differentiation
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک دانش گیاه شناسی
پیش نمایش صفحه اول مقاله
Expression of S100A8/A9 in HaCaT keratinocytes alters the rate of cell proliferation and differentiation
چکیده انگلیسی
S100A8/A9 promotes NADPH oxidase in HaCaT keratinocytes and subsequently increases NFκB activation, which plays important roles in the balance between epidermal growth and differentiation. S100A8/A9-positive HaCaT cells present with a significantly reduced rate of cell division and greater expression of two keratinocyte differentiation markers, involucrin and filaggrin, than control cells. S100A8/A9 mutants fail to enhance NFκB activation, TNFα-induced IL-8 gene expression and NFκB p65 phosphorylation, and S100A8/A9-positive cells demonstrate better cell survival in forced suspension culture than mutant cells. S100A8/A9 is induced in epithelial cells in response to stress. Therefore, S100A8/A9-mediated growth arrest could have implications for tissue remodeling and repair.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: FEBS Letters - Volume 585, Issue 2, 21 January 2011, Pages 440-446
نویسندگان
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