کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10872555 | 1074179 | 2007 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Do mitochondria act as “cargo boats” in the journey of GD3 to the nucleus during apoptosis?
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم کشاورزی و بیولوژیک
دانش گیاه شناسی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Plasma membrane lipid rafts have been considered as a sort of “chamber”, where several subcellular activities, including CD95/Fas-mediated pro-apoptotic signaling, can take place. Recently, we demonstrated that, after CD95/Fas triggering, raft-like microdomains could be detected in mitochondrial membranes. The mitochondrion appears as a dynamic and subcompartmentalized organelle in which microdomains might act as controllers of apoptosis-associated fission that results in the release of apoptogenic factors. Here, we hypothesize that some “small” mitochondria, possibly derived from their fission process, can reach the nuclear envelope and strictly interact with this. Mitochondria could act as a signaling “device” contributing to molecular trafficking of molecules, including raft-like components, during apoptosis.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: FEBS Letters - Volume 581, Issue 21, 21 August 2007, Pages 3899-3903
Journal: FEBS Letters - Volume 581, Issue 21, 21 August 2007, Pages 3899-3903
نویسندگان
Tina Garofalo, Antonella Tinari, Paola Matarrese, Anna Maria Giammarioli, Valeria Manganelli, Laura Ciarlo, Roberta Misasi, Maurizio Sorice, Walter Malorni,