کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10883950 | 1078817 | 2005 | 21 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Physical methods for gene transfer: Improving the kinetics of gene delivery into cells
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
بیوتکنولوژی یا زیستفناوری
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Physical methods for gene transfer: Improving the kinetics of gene delivery into cells Physical methods for gene transfer: Improving the kinetics of gene delivery into cells](/preview/png/10883950.png)
چکیده انگلیسی
One factor critical to successful gene therapy is the development of efficient delivery systems. Although advances in gene transfer technology, including viral and non-viral vectors, have been made, an ideal vector system has not yet been constructed. This review describes the basic principles behind various physical methods for gene transfer and assesses the advantages and performance of such approaches, compared to other transfection systems. In particular, the kinetics and efficiency of gene delivery, the toxicity, in vivo feasibility, and targeting ability of different physical methodologies are discussed and evaluated.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Advanced Drug Delivery Reviews - Volume 57, Issue 5, 5 April 2005, Pages 733-753
Journal: Advanced Drug Delivery Reviews - Volume 57, Issue 5, 5 April 2005, Pages 733-753
نویسندگان
Sophie Mehier-Humbert, Richard H. Guy,