کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10884380 | 1078961 | 2005 | 20 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Monitoring drug delivery processes by EPR and related techniques-principles and applications
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
بیوتکنولوژی یا زیستفناوری
پیش نمایش صفحه اول مقاله
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چکیده انگلیسی
Electron Paramagnetic Resonance (EPR, or ESR) is a powerful non-invasive spectroscopic tool that can be used to monitor drug release processes in vitro and in vivo. Furthermore, spatial dissolution can be achieved by means of EPR-Imaging. The article introduces the basics of EPR and EPR-imaging. It discusses also the challenges of in vivo spectroscopy and imaging and presents information about new developments such as longitudinally detected EPR (LODEPR) and Proton Electron Double Resonance Imaging ((PEDRI). Examples of the usefulness of EPR in the field of drug delivery include the measurement of microviscosity and micropolarity, the direct detection of drug release mechanisms in vitro and in vivo, the monitoring of microacidity in biodegradable polymers and the characterisation of colloidal drug carriers.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Advanced Drug Delivery Reviews - Volume 57, Issue 8, 15 June 2005, Pages 1171-1190
Journal: Advanced Drug Delivery Reviews - Volume 57, Issue 8, 15 June 2005, Pages 1171-1190
نویسندگان
David J. Lurie, Karsten Mäder,