کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10884703 | 1079481 | 2005 | 18 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
A statistical analysis of the TRANSFAC database
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موضوعات مرتبط
مهندسی و علوم پایه
ریاضیات
مدلسازی و شبیه سازی
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چکیده انگلیسی
Transcription factors are key regulatory elements that control gene expression. The TRANSFAC® database represents the largest repository for experimentally derived transcription factor binding sites (TFBS). Understanding TFBS, which are typically conserved during evolution, helps us identify genomic regions related to human health and disease, and regions that might be predictive of patient outcomes. Here we present a statistical analysis of all TFBS in the TRANSFAC® database. Our analysis suggests that current definition of TFBS core regions in TRANSFAC® should be re-examined so as to capture a more precise notion of “cores.” We offer insight into more appropriate definitions of TFBS consensus sequences and core regions. These revised definitions provide a better understanding of the nature of transcription factor-DNA binding and assist with developing algorithms for de novo TFBS discovery as well as finding novel variants of known TFBS.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biosystems - Volume 81, Issue 2, August 2005, Pages 137-154
Journal: Biosystems - Volume 81, Issue 2, August 2005, Pages 137-154
نویسندگان
Gary B. Fogel, Dana G. Weekes, Gabor Varga, Ernst R. Dow, Andrew M. Craven, Harry B. Harlow, Eric W. Su, Jude E. Onyia, Chen Su,