کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10886299 1080017 2005 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Formulation strategies for absorption windows
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیوتکنولوژی یا زیست‌فناوری
پیش نمایش صفحه اول مقاله
Formulation strategies for absorption windows
چکیده انگلیسی
Absorption windows in the proximal gut can limit the bioavailability of orally administered compounds and can be a major obstacle to the development of controlled release formulations for important drugs. Methods to increase the residence of drug formulations at or above the absorption window are discussed in this review. Two main approaches are presently being explored: (i) bioadhesive microspheres that have a slow intestinal transit; and (ii) the gastroretentive dosage system, which is based on multiparticulates or large single unit systems. A good understanding of gastrointestinal transit in humans and the effect of factors such as food can be helpful in the design of rational systems that will have clinical benefit.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Drug Discovery Today - Volume 10, Issue 4, 15 February 2005, Pages 249-257
نویسندگان
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