کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10886408 | 1080025 | 2005 | 14 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Perspectives for cytokine antagonist therapy in COPD
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
بیوتکنولوژی یا زیستفناوری
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Perspectives for cytokine antagonist therapy in COPD Perspectives for cytokine antagonist therapy in COPD](/preview/png/10886408.png)
چکیده انگلیسی
Chronic obstructive pulmonary disease (COPD) is an inflammatory lung disease associated with progressive airflow limitation. The main risk factor is tobacco smoking. Anti-inflammatory therapies (e.g. corticosteroids) are based on those developed initially for asthma. In contrast to asthma, they are rather ineffective in improving chronic symptoms and reducing inflammation and lung function decline. Specific drugs need to be developed directed against this chronic inflammation, thereby preventing lung tissue damage. Cytokine antagonists for tumour necrosis factor α, interleukin 8 receptor, interleukin 1, and specific signal transduction inhibitors have proven to be effective for other inflammatory diseases. Their efficacy for COPD therapy has yet to be demonstrated.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Drug Discovery Today - Volume 10, Issue 2, 15 January 2005, Pages 93-106
Journal: Drug Discovery Today - Volume 10, Issue 2, 15 January 2005, Pages 93-106
نویسندگان
Willem I. de Boer,