Keywords: بیولوژی شیمیایی; Cysteine; Cysteine sulfenic acid; Norbornene; Oxidative stress; Chemical biology;
مقالات ISI بیولوژی شیمیایی (ترجمه نشده)
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در صورتی که به ترجمه آماده هر یک از مقالات زیر نیاز داشته باشید، می توانید سفارش دهید تا مترجمان با تجربه این مجموعه در اسرع وقت آن را برای شما ترجمه نمایند.
Keywords: بیولوژی شیمیایی; Natural products; Salinomycin; Molecular editing; Coordination chemistry; Cancer; Cancer stem cells; Iron; Fenton chemistry; Medicinal chemistry; Chemical biology;
Keywords: بیولوژی شیمیایی; Chemical biology; Fluorescent probes; Proteins; Enzymes; Kemp elimination;
Keywords: بیولوژی شیمیایی; Calcium probe; Plant cell; Chemical biology;
Keywords: بیولوژی شیمیایی; chemical biology; network pharmacology; systems biology; traditional Chinese medicines
Keywords: بیولوژی شیمیایی; Natural and traditional medicines; Target identification; Chemical biology; Quantitative proteomics; SILAC; iTRAQAkt, protein kinase B; CSNK1G3, casein kinase 1, gamma 3; DMSO, dimethyl sulfoxide; ICAT, isotope-coded affinity tag; iTRAQ, isobaric tag for
Keywords: بیولوژی شیمیایی; Natural product; Oridonin; Diterpenoids; Anticancer agents; Drug discovery; Chemical biology
Keywords: بیولوژی شیمیایی; Fluorescent probes; Golgi apparatus; Chemical biology; Natural products; Kapakahine;
Keywords: بیولوژی شیمیایی; High throughput screening; Fragment screening; Drug discovery; Chemical biology; Acoustic droplet ejection; In situ X-ray data collection; Crystallography; Synchrotron radiation;
Keywords: بیولوژی شیمیایی; Chemical biology; Oxazine; Acetylcholinesterase; Lipoxygenase; Alzheimer disease;
Keywords: بیولوژی شیمیایی; Glycopeptide; Isostere; Peptidomimetic; Deacetylation; Carbohydrate; Chemical biology
Keywords: بیولوژی شیمیایی; induced pluripotent stem cells; small molecules; reprogramming; chemical biology; epigenetics
Keywords: بیولوژی شیمیایی; Fungi; Natural products; Microbiology; Molecular genetics; Chemical biology
Tauroursodeoxycholic acid binds to the G-protein site on light activated rhodopsin
Keywords: بیولوژی شیمیایی; Bile acid; Chemical biology; G protein; G proteinâcoupled receptor (GPCR); Molecular docking; Photoreceptor; Phototransduction; Retina; Rhodopsin; Signal transduction; GPCR; G-protein coupled receptor; G-protein; heterotrimeric GTP-binding protein; R; d
A small diversity library of α-methyl amide analogs of sulindac for probing anticancer structure-activity relationships
Keywords: بیولوژی شیمیایی; NSAID; non-steroidal anti-inflammatory drug; COX; cyclooxygenase; PG; prostaglandin; FAP; familial adenomatous polyposis; SSA; sulindac sulfide amide; SAR; structure-activity relationship; qHTS; quantitative high-throughput screen; CPC; choroid plexus car
Protein ligand-tethered synthetic calcium indicator for localization control and spatiotemporal calcium imaging in plant cells
Keywords: بیولوژی شیمیایی; Plant cell; Calcium indicator; Natural products; Chemical biology
A phenotypic drug discovery study on thienodiazepine derivatives as inhibitors of T cell proliferation induced by CD28 co-stimulation leads to the discovery of a first bromodomain inhibitor
Keywords: بیولوژی شیمیایی; CD28; Phenotypic drug discovery; Chemical biology; BET family; Bromodomain; Immunosuppressant; Anti-cancer
CRISPR-Mediated Drug-Target Validation Reveals Selective Pharmacological Inhibition of the RNA Helicase, eIF4A
Keywords: بیولوژی شیمیایی; rocaglates; eIF4A; translational control; chemical biology; CRISPR/Cas9
DREADDs for Neuroscientists
Keywords: بیولوژی شیمیایی; DREADD; chemogenetic; chemical biology; synthetic biology
Expansion of the Chlamydia trachomatis inclusion does not require bacterial replication
Keywords: بیولوژی شیمیایی; Chlamydia trachomatis; Chemical biology; Inclusion expansion; Bacterial replication;
Helix mimetics: Recent developments
Keywords: بیولوژی شیمیایی; Protein-protein interactions; Inhibitors; α-Helix; α-Helix mimetic; Chemical biology;
Chemical chronobiology: Toward drugs manipulating time
Keywords: بیولوژی شیمیایی; Circadian rhythm; Small molecule compound; High-throughput screening; Chemical biology;
Targeting the eIF4A RNA helicase as an anti-neoplastic approach
Keywords: بیولوژی شیمیایی; Translation; eIF4A; eIF4F; Chemical biology; Cancer
Towards a systematic analysis of human short-chain dehydrogenases/reductases (SDR): Ligand identification and structure–activity relationships
Keywords: بیولوژی شیمیایی; Short-chain dehydrogenase/reductase; Chemical biology; Structural genomics; Differential scanning fluorimetry; Metabolism
Love-Hate ligands for high resolution analysis of strain in ultra-stable protein/small molecule interaction
Keywords: بیولوژی شیمیایی; D, Dead; non-binding streptavidin mutant; EC50; half-maximal effective concentration; L3/4; loop connecting β-strands 3 and 4; LH; Love-Hate ligand; rmsd; root mean square deviation; SA; wild-type core streptavidin; SAe; core streptavidin with C-termin
Retinoic acid signaling pathways in development and diseases
Keywords: بیولوژی شیمیایی; Retinoids; Chemical biology; Boron retinoids; Retinoids imaging; Nuclear receptors; Retinoic acid; Vitamin A
Molecular basis of transcriptional fidelity and DNA lesion-induced transcriptional mutagenesis
Keywords: بیولوژی شیمیایی; RNA polymerase II; Transcription elongation; Fidelity control; DNA damage recognition; Transcriptional lesion bypass; Synthetic nucleotide analogs; Unlocked nucleic acid; Nonpolar isostere; Chemical biology; Structural biology; Computational biology;
Small-molecule modulators of 14-3-3 protein-protein interactions
Keywords: بیولوژی شیمیایی; PPI inhibitors; PPI stabilizers; Protein-protein interactions; Drug development; Chemical biology;
Degradation of MAC13243 and studies of the interaction of resulting thiourea compounds with the lipoprotein targeting chaperone LolA
Keywords: بیولوژی شیمیایی; Chemical biology; Structure-activity relationship; Lipoprotein trafficking; LolA; MreB; Chemical-genetic interactions;
A systems chemical biology study of malate synthase and isocitrate lyase inhibition in Mycobacterium tuberculosis during active and NRP growth
Keywords: بیولوژی شیمیایی; Biological networks; Cheminformatics; Biochemical network simulations; Systems biology; Chemical biology; Mycobacterium tuberculosis;
Chemical biology approaches for the study of apicomplexan parasites
Keywords: بیولوژی شیمیایی; Apicomplexan; Chemical biology; Small molecule; Bioorthogonal
N-acetyl cysteine as an osteogenesis-enhancing molecule for bone regeneration
Keywords: بیولوژی شیمیایی; Anti-oxidant; Chemical biology; Growth factor; Multi-function; Osteostimulation
An Approach to Quantify Endomembrane Dynamics in Pollen Utilizing Bioactive Chemicals
Keywords: بیولوژی شیمیایی; endomembranes; vesicle trafficking; quantification; pollen; chemical biology
Identification and validation of protein targets of bioactive small molecules
Keywords: بیولوژی شیمیایی; Target identification; Target validation; Chemical biology; Small molecules; Protein targets;
Cleavable linkers in chemical biology
Keywords: بیولوژی شیمیایی; Cleavable linker; Chemical biology; Proteomic; ABPP; Biocompatible;
Nucleic acid based tools for pharmacology and nano-engineering
Keywords: بیولوژی شیمیایی; Aptamers; Ribozymes; SELEX; Chemical biology; High-throughput screening; DNA architectures
Elucidating the functionality of kinesins: An overview of small molecule inhibitors
Keywords: بیولوژی شیمیایی; AMP-PCP; 5â²-adenylyl (beta, gamma-methylene)diphosphonate; AMP-PNP; adenylyl-imidodiphosphate; AS; adociasulfate; CENP-E; centromere-associated protein-E; DPC-4; deleted in pancreas cancer locus 4; Hklp2; human kinesin-like protein 2; HSET; human spleen
Identification and further development of thiazolidinones spiro-fused to indolin-2-ones as potent and selective inhibitors of Mycobacterium tuberculosis protein tyrosine phosphatase B
Keywords: بیولوژی شیمیایی; Chemical biology; Enzyme inhibitors; Medicinal chemistry; Molecular modeling;
The cytotoxic styryl lactone goniothalamin is an inhibitor of nucleocytoplasmic transport
Keywords: بیولوژی شیمیایی; Natural products; Chemical biology; Target identification; Organic synthesis
The Privileged Chemical Space Predictor (pcsp): A computer program that identifies privileged chemical space from screens of modularly assembled chemical libraries
Keywords: بیولوژی شیمیایی; RNA; Chemical biology; High-throughput screening; Chemical microarrays; Computer program; Chemical space
Small-molecule regulators that mimic transcription factors
Keywords: بیولوژی شیمیایی; Chemical biology; Synthetic biology; Transcription factor mimic; Gene regulation; Cooperative binding; Protein–DNA interaction
A survey of yeast genomic assays for drug and target discovery
Keywords: بیولوژی شیمیایی; Yeast; Chemical genomics; Chemical biology; Drug target; Drug actionYKO, Yeast KnockOut collection; HIP, HaploInsufficiency Profiling; MSP, Multi-copy suppression profiling; SGA, Synthetic genetic array; ORF, Open reading frame; MoBY-ORF, Molecular-barcod
Zn(II)-dependent histone deacetylase inhibitors: Suberoylanilide hydroxamic acid and trichostatin A
Keywords: بیولوژی شیمیایی; Zn(II)-dependent histone deacetylases; Suberoylanilide hydroxamic acid; Trichostatin A; Hydroxamic acids; Chemical biology;
A new paradigm for protein design and biological self-assembly
Keywords: بیولوژی شیمیایی; Chemical biology; Membrane proteins; Antimicrobial peptides; Anti-diabetic therapeutics
Preparation and fluorescence properties of fluorophore-labeled avidin–biotin system immobilized on Fe3O4 nanoparticles through functional indolequinone linker
Keywords: بیولوژی شیمیایی; Chemical biology; Molecular imaging; Hypoxia; Magnetic nanoparticles; Indolequinone
High-throughput assays probing protein–RNA interactions of eukaryotic translation initiation factors
Keywords: بیولوژی شیمیایی; Chemical biology; Translation; Small-molecule screening; HTS assay; p-Chloromercuribenzoate
Synthesis and structure–activity relationships of dehydroaltenusin derivatives as selective DNA polymerase α inhibitors
Keywords: بیولوژی شیمیایی; Structure–activity relationships; DNA polymerase inhibitor; Natural product synthesis; Dehydroaltenusin; Chemical biology
Membrane binding of lipidated Ras peptides and proteins — The structural point of view
Keywords: بیولوژی شیمیایی; Lipid modification; Chemical biology; Solid-state NMR spectroscopy; Molecular dynamics simulation; Signal transduction
Design and synthesis of regioisomerically pure unsymmetrical xanthene derivatives for staining live cells and their photochemical properties
Keywords: بیولوژی شیمیایی; Unsymmetrical xanthene derivatives; Regioisomerically pure; Photochemical properties; Chemical biology
Enzyme-independent, orientation-selective conjugation of whole human complement C3 to protein surfaces
Keywords: بیولوژی شیمیایی; Complement, Thioester; Adjuvant; Chemical biology; Sulfo EMCS; sulfo-ε-maleimidocaproyloxysuccinimide;