کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
8320902 1539409 2014 13 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Molecular basis of transcriptional fidelity and DNA lesion-induced transcriptional mutagenesis
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
Molecular basis of transcriptional fidelity and DNA lesion-induced transcriptional mutagenesis
چکیده انگلیسی
Maintaining high transcriptional fidelity is essential for life. Some DNA lesions lead to significant changes in transcriptional fidelity. In this review, we will summarize recent progress towards understanding the molecular basis of RNA polymerase II (Pol II) transcriptional fidelity and DNA lesion-induced transcriptional mutagenesis. In particular, we will focus on the three key checkpoint steps of controlling Pol II transcriptional fidelity: insertion (specific nucleotide selection and incorporation), extension (differentiation of RNA transcript extension of a matched over mismatched 3′-RNA terminus), and proofreading (preferential removal of misincorporated nucleotides from the 3′-RNA end). We will also discuss some novel insights into the molecular basis and chemical perspectives of controlling Pol II transcriptional fidelity through structural, computational, and chemical biology approaches.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: DNA Repair - Volume 19, July 2014, Pages 71-83
نویسندگان
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