Synthesis and characterization of novel 1,2-oxazine-based small molecules that targets acetylcholinesterase

Thirteen 2-oxazine-substituted heterocyclic derivatives were synthesized targeting 5-LOX and AChE. The test revealed that the newly synthesized compounds had potent inhibition towards both 5-LOX and AChE in lower micro molar concentration (Scheme 1, FG = functional groups).