کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10886679 | 1080046 | 2005 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Tinnitus: neurobiological substrates
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
بیوتکنولوژی یا زیستفناوری
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چکیده انگلیسی
Tinnitus is an auditory phantom sensation of ringing in the ears that is experienced when no external sound is present. It is a prevalent disorder that is frequently caused by insults to the peripheral auditory and somatosensory systems, especially in the elderly. This creates an imbalance between inhibitory and excitatory transmitter actions in the midbrain, auditory cortex and brainstem (where neural activity from somatosensory and auditory stimuli interact). This imbalance causes hyperexcitability often leading to the perception of phantom sounds. Although changes in transmitter-receptor systems have become better documented, there are currently no proven drug treatments for humans. Methods for preventing tinnitus have been demonstrated in animal studies.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Drug Discovery Today - Volume 10, Issue 19, 1 October 2005, Pages 1283-1290
Journal: Drug Discovery Today - Volume 10, Issue 19, 1 October 2005, Pages 1283-1290
نویسندگان
Jos J. Eggermont,