Establishment of a human CEACAM1 transgenic mouse model for the study of gonococcal infections

► The hCD46 promoter was used to drive expression of hCEACAM1 cDNA in transgenic mice. ► The hCEACAM1 protein was expressed in various tissues including vaginal tissue. ► The hCEACAM1 protein was expressed on the cell membrane. ► N. gonorrhoeae can infect and cause inflammation in transgenic mice.