کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10895331 1083018 2005 14 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Microarray studies of prognostic stratification and transformation of follicular lymphomas
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی تحقیقات سرطان
پیش نمایش صفحه اول مقاله
Microarray studies of prognostic stratification and transformation of follicular lymphomas
چکیده انگلیسی
Follicular lymphoma (FL) is a common, indolent malignancy with a natural history of transformation to the more aggressive form of diffuse large B-cell lymphoma (DLBCL) in 25-60% of cases. In order to understand the pathogenesis of lymphoma genesis and evolution, the molecular changes characteristic of FL and transformed DLBCL are being studied. The most common abnormality associated with FL is the t(14;18)(q32;q21) chromosomal translocation, but many more molecular aberrations have been found in patient subgroups. The study of gene expression profiling using DNA microarrays enables large scale, comparative analyses of gene expression. Its implementation in the research on FL has led to advances in disease diagnosis and classification and has the potential to lead to pathogenesis-based individualised therapies.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Best Practice & Research Clinical Haematology - Volume 18, Issue 1, March 2005, Pages 143-156
نویسندگان
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