کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10895579 1083084 2014 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The emerging role of RNA and DNA editing in cancer
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی تحقیقات سرطان
پیش نمایش صفحه اول مقاله
The emerging role of RNA and DNA editing in cancer
چکیده انگلیسی
Sequence editing provides an additional regulatory layer of cancer initiation and progression that may be amenable to therapeutic design. Although editing of both RNA and DNA substrates has been known to occur for some time, the extent and implications of these modifications have been grossly underappreciated until recent genome-wide and disease-association studies were reported. This review highlights the cellular processes controlled by sequence editing, their implications in normal and cancerous states and considers potential targeted therapeutic strategies.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochimica et Biophysica Acta (BBA) - Reviews on Cancer - Volume 1845, Issue 2, April 2014, Pages 308-316
نویسندگان
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