کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10895610 | 1083086 | 2014 | 19 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Molecular functions of the iron-regulated metastasis suppressor, NDRG1, and its potential as a molecular target for cancer therapy
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کلمات کلیدی
DPCNIHEGR1HDL-CHIF-1αLPCECMHUVECETsDPTHsc70CPT-11DFODp44mTMMPNF-κBNDRG1HTEAkt - آکتIrinotecan - ایرینوتکانinterleukin - اینترلوکینHuman umbilical vein endothelial cell - سلول اندوتلیالی ورید ناقل انسانیhypoxia inducible factor-1α - عامل القایی هیپوکسی 1αnuclear factor-κB - فاکتور هسته ای κBLysophosphatidylcholine - لیزوفسفاتیدیل کولینhigh-density lipoprotein cholesterol - لیپوپروتئین پرچگالی یا اچدیالLow-density lipoprotein - لیپوپروتئین کم چگالی یا الدیال LDL - لیپوپروتئین کم چگالی(کلسترول بد)Extracellular matrix - ماتریکس خارج سلولیmatrix metalloproteinase - ماتریکس متالوپروتئینازprotein kinase B - پروتئین کیناز B
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
تحقیقات سرطان
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
N-myc down-regulated gene 1 (NDRG1) is a known metastasis suppressor in multiple cancers, being also involved in embryogenesis and development, cell growth and differentiation, lipid biosynthesis and myelination, stress responses and immunity. In addition to its primary role as a metastasis suppressor, NDRG1 can also influence other stages of carcinogenesis, namely angiogenesis and primary tumour growth. NDRG1 is regulated by multiple effectors in normal and neoplastic cells, including N-myc, histone acetylation, hypoxia, cellular iron levels and intracellular calcium. Further, studies have found that NDRG1 is up-regulated in neoplastic cells after treatment with novel iron chelators, which are a promising therapy for effective cancer management. Although the pathways by which NDRG1 exerts its functions in cancers have been documented, the relationship between the molecular structure of this protein and its functions remains unclear. In fact, recent studies suggest that, in certain cancers, NDRG1 is post-translationally modified, possibly by the activity of endogenous trypsins, leading to a subsequent alteration in its metastasis suppressor activity. This review describes the role of this important metastasis suppressor and discusses interesting unresolved issues regarding this protein.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochimica et Biophysica Acta (BBA) - Reviews on Cancer - Volume 1845, Issue 1, January 2014, Pages 1-19
Journal: Biochimica et Biophysica Acta (BBA) - Reviews on Cancer - Volume 1845, Issue 1, January 2014, Pages 1-19
نویسندگان
Bernard A. Fang, Žaklina KovaÄeviÄ, Kyung Chan Park, Danuta S. Kalinowski, Patric J. Jansson, Darius J.R. Lane, Sumit Sahni, Des R. Richardson,