کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10896911 | 1083814 | 2005 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Breast cancer risk factors according to joint estrogen receptor and progesterone receptor status
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کلمات کلیدی
Menarchefamily history - سابقه خانوادگیBreast cancer - سرطان پستانAge - سنSmoking - سیگار کشیدنBMI - شاخص توده بدنیLactation - شیردهیRisk factor - عامل خطرRace - مسابقهAlcohol intake - مصرف الکلHormone - هورمونMenopausal status - وضعیت یائسگیEstrogen receptor - گیرنده استروژنProgesterone receptor - گیرنده پروژسترون
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
تحقیقات سرطان
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Background: We investigated risk factor patterns for subtypes of breast cancer characterized by joint estrogen receptor (ER) and progesterone receptor (PR) status in a hospital-based case-control study. Methods: ER and PR tumor status were determined immunohisotchemically. Risk factors of interest were entered into a multiple polychotomous logistic regression model simultaneously; odds ratios (ORs) and 95% confidence intervals (CIs) were calculated. Using this model, cases in the four tumor subtypes (ER+PR+, ERâPRâ, ER+PRâ, ERâPR+) were compared simultaneously to controls. A Wald test for heterogeneity across the four subtypes was conducted, as well as a case-case comparison between the two most biologically disparate subtypes, ER+PR+ and ERâPRâ. Results: The receptor status distribution was as follows: 33% ER+PR+, 34% ERâPRâ, 20% ER+PRâ, and 13% ERâPR+. Among 317 cases and 401 controls, we found significant heterogeneity across the four tumor subtypes for older age at first full-term pregnancy (p = 0.04) and post-menopausal status (p = 0.04). For older age at first full-term pregnancy, an elevated risk was found for the ER+PRâ subtype (OR = 2.5; 95% CI: 1.2-5.1). For post-menopausal status, elevated risks were found for both the ER+PR+ (OR = 2.4; 95% CI: 1.1-4.9) and ER+PRâ (OR = 7.2; 95% CI: 2.4-21.7) subtypes. From the case-case comparisons, we found that cases, who had consumed alcohol for more than 1 year were 3.4 times more likely to have ER+PR+ tumors than ERâPRâ tumors (95% CI: 1.4-8.4). Conclusions: Certain breast cancer risk factors may vary by ER and PR status, and joint ER/PR status should be taken into account in future studies of risk factor estimates.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Cancer Detection and Prevention - Volume 29, Issue 5, 2005, Pages 419-426
Journal: Cancer Detection and Prevention - Volume 29, Issue 5, 2005, Pages 419-426
نویسندگان
Jennifer A. PhD, Theodore R. PhD, Shelia H. PhD, Tongzhang DSc,