کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10899522 | 1084387 | 2015 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Immunological features of T cells induced by human telomerase reverse transcriptase-derived peptides in patients with hepatocellular carcinoma
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کلمات کلیدی
TAAPBMCELISPOTHuman leukocyte antigen - آنتی ژن لوسکسی انسانtumor-associated antigen - آنتی ژن مرتبط با تومورHLA - آنتیژن گلبول سفید انسانیEpitope - اپیتوپEnzyme-linked immunospot - ایمنی مصنوعی مرتبط با آنزیمimmunotherapy - ایمونوتراپیinterferon - اینترفرونIFN - اینترفرون هاCancer - سرطانCytotoxic T cell - سلول T سیتوتوکسیکPeripheral blood mononuclear cell - سلول تک هسته ای خون محیطیHepatitis C virus - هپاتیت سیHCV - هپاتیت سیT cell receptor - گیرنده سلول T
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
تحقیقات سرطان
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Immunological features of T cells induced by human telomerase reverse transcriptase-derived peptides in patients with hepatocellular carcinoma Immunological features of T cells induced by human telomerase reverse transcriptase-derived peptides in patients with hepatocellular carcinoma](/preview/png/10899522.png)
چکیده انگلیسی
Human telomerase reverse transcriptase (hTERT) is a catalytic enzyme required for telomere elongation. In this study, we investigated the safety and immunogenicity of an hTERT-derived peptide (hTERT461) as a vaccine and characterized the hTERT-specific T cell responses induced. Fourteen hepatocellular carcinoma (HCC) patients were enrolled in the study. The hTERT-derived peptide was emulsified in incomplete Freund's adjuvant and administered via subcutaneous immunization three times biweekly. The maximum toxicity observed was grade 2 according to the common terminology criteria and mainly consisted of skin reactions at the site of vaccination. The vaccination induced hTERT-specific immunity in 71.4% of patients and 57.1% of patients administered with hTERT461 peptide-specific T cells could prevent HCC recurrence after vaccination. In phenotypic analysis, the post-vaccinated increase in hTERT-specific T cells was due to an increase in cells with the effector memory phenotype, with the potential to produce multiple cytokines. Seven hTERT-specific T cell receptors were obtained from the vaccinated patients, showing their cytotoxic activities to hTERT-derived peptide-bearing cells. In conclusion, the safety and effects of immune boosting by hTERT461 peptide have shown the potential of the peptide to provide clinical benefits in HCC patients.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Cancer Letters - Volume 364, Issue 2, 10 August 2015, Pages 98-105
Journal: Cancer Letters - Volume 364, Issue 2, 10 August 2015, Pages 98-105
نویسندگان
Eishiro Mizukoshi, Hidetoshi Nakagawa, Masaaki Kitahara, Tatsuya Yamashita, Kuniaki Arai, Hajime Sunagozaka, Kazumi Fushimi, Eiji Kobayashi, Hiroyuki Kishi, Atsushi Muraguchi, Shuichi Kaneko,