کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10899556 | 1084394 | 2015 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Regulation and function of Myb-binding protein 1A (MYBBP1A) in cellular senescence and pathogenesis of head and neck cancer
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کلمات کلیدی
VHLSASPSAHFHNSCCMYBBP1ASA-β-galNF1OPSCCDDRNFκB - NFKBPFs - PF هاsenescence-associated β-galactosidase - β-گالاکتوزیداز وابسته به پیریDNA damage - آسیبDNAVon Hippel–Lindau - از Hippel-Lindauoverall survival - بقای کلCancer - سرطانTreatment failure - شکست درمانnuclear factor kappa B - فاکتور هسته ای کاپا Bphosphatase and tensin homolog - فسفاتاز و تنسین همولوگSenescence-associated secretory phenotype - فنوتیپ ترشحی مرتبط با سن زاییDNA damage response - واکنش به آسیب DNA Stress response - پاسخ به استرسPten - ژن PTENOropharyngeal squamous cell carcinoma - کارسینوم سلول سنگفرشی اوروفارینگزHead and neck squamous cell carcinoma - کارسینوم سلول سنگفرشی سر و گردنsenescence-associated heterochromatic foci - کانون های هتروکروماتیک مرتبط با پیری
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
تحقیقات سرطان
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Regulation and function of Myb-binding protein 1A (MYBBP1A) in cellular senescence and pathogenesis of head and neck cancer Regulation and function of Myb-binding protein 1A (MYBBP1A) in cellular senescence and pathogenesis of head and neck cancer](/preview/png/10899556.png)
چکیده انگلیسی
Myb-binding protein 1A (MYBBP1A) is a nucleolar protein implicated in stress response and carcinogenesis; however, its functional contribution to senescence remains elusive. In this study we show decreased MYBBP1A protein levels in tumor cells after treatment with etoposide, a potent inducer of DNA damage. Although silencing of MYBBP1A expression was not sufficient to induce senescence, it significantly increased the relative abundance of senescent cells after DNA damage. We found an inverse regulation of MYBBP1A and AKT phosphorylation (pAKT(Ser473)), which was characteristic for the pre-senescent state after etoposide administration in vitro. Tissue microarrays with tumor specimens from primary oropharyngeal squamous cell carcinoma (OPSCC) patients (nâ=â61) by immunohistochemistry revealed a significant correlation between MYBBP1AlowpAKT(Ser473)high staining pattern and shorter progression-free (pâ=â0.007) or overall survival (pâ<â0.001). Multivariate analysis showed that MYBBP1AlowpAKT(Ser473)high staining pattern is an independent prognosticator for OPSCC. Taken together, our study points to a critical role of MYBBP1A in the regulation of senescence under genotoxic stress and that a MYBBP1AlowAKT(Ser473)high staining pattern serves not only as a marker for the pre-senescent stage but also as an indicator of OPSCC patients at high risk for treatment failure.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Cancer Letters - Volume 358, Issue 2, 28 March 2015, Pages 191-199
Journal: Cancer Letters - Volume 358, Issue 2, 28 March 2015, Pages 191-199
نویسندگان
Babitha George, Dominik Horn, Pilar Bayo, Karim Zaoui, Christa Flechtenmacher, Niels Grabe, Peter Plinkert, Valery Krizhanovsky, Jochen Hess,