Keywords: Bax; Bcl-2-associated X protein; CHOP; C/EBP-homologous protein 10; DNA; dezoxiribonucleic acid; FITC; fluorescein isothiocyanate; GAPDH; (Glyceraldehyde 3-phosphate dehydrogenase; GRP78; glucose-regulated protein 78; HIF1α; hypoxia inducible factor 1α;
مقالات ISI (ترجمه نشده)
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Keywords: Cnt-Pr; CnT-Prime, epithelial culture medium; CCK; cell counting kit; DMEM; Dulbecco's modified eagle medium; DPBS; Dulbecco's phosphate-buffered saline; EDTA; ethylene diamine tetraacetic acid; FBS; fetal bovine serum; FITC; fluorescein isothiocyanat
Keywords: ARE; Antioxidant Response Elements; BDNF; Brain-Derived Neurotrophic Factor; Eph; Ephrine; EphR; Ephrine Receptor; GADD45α; Growth Arrest and DNA Damage Inducible 45α; GS; Glutamine Synthetase; HE; Hepatic Encephalopathy; HO1; Heme Oxygenase 1; LOLA; l-
Keywords: Sporadic/hereditary pituitary tumors; Whole genome/exome sequencing; USP8 mutation; Pituitary adenoma progression; Pituitary carcinoma; Pituitary tumor senescence; AIP; aryl hydrocarbon-interacting protein; BC; bromocriptine; bFGF; basic fibroblast growth
Keywords: CCCP; Carbonyl cyanide 3-chlorophenylhydrazone; COX IV; Cytochrome c oxidase subunit IV; DAPI; 4â²,6-Diamidino-2-phenylindole dihydrochloride; DMEM; Dulbecco's Modified Eagle Medium; DMSO; Dimethyl sulfoxide; Drp-1; Dynamin-related protein 1; DNPH; 2,4-d
Keywords: constrictive pericarditis; pericardial interstitial cell; senescence; structural remodeling; BMP; bone morphogenetic protein; DMEM; Dulbecco's modified Eagle's medium; ECM; extracellular matrix; IPCP; idiopathic and postsurgical constrictive pericarditis;
Keywords: CM; conditioned medium; OCCs; ovarian cancer cells; CPD; cumulative number of population doublings; Cx43; connexin 43; H2O2; hydrogen peroxide; HGF; hepatocyte growth factor; HPMCs; human peritoneal mesothelial cells; JC-1; 5,5',6,6'-tetrachloro-1,1',3,3'
Keywords: Cit-GNPs; citric-acid-capped gold nanoparticles; GJ; Gardenia jasminoides; GJ-GNP; Gardenia jasminoides extract-capped gold nanoparticle; RPE; retinal pigment epithelial; ROS; reactive oxygen species; SA-β-gal; senescence-associated β-galactosidase; Cel
Keywords: mTORC1; mammalian target of rapamycin complex 1; SADF; senescence-associated DNA damage foci; SAHF; senescence-associated heterochromatic foci; SASP; senescence-associated secretory phenotype; SA-β-GAL; senescence-associated β-galactosidase; Cellular se
Keywords: BrdU; bromodeoxyuridine; DR; dietary restriction; gfap; glial fibrillary acidic protein; GFP; green fluorescent protein; qPCR; quantitative polymerase chain reaction; SA-β-gal; senescence associated β-galactosidase; TRF; telomeric terminal restriction f
Keywords: COPD; chronic obstructive pulmonary disease; RS; replicative senescence; SIPS; stress induced premature senescence; OIS; oncogene induced senescence; SASP; senescence associated secretory phenotype; TNF-a; tumor necrosis factor-a; TNFR1; TNFa receptor 1;
Keywords: Acrylamide; Endothelial cell; Senescence; Hayflick's limit; Telomere length shortening; AAM; acrylamide; C12FDG; d-galactopyranoside; CPD; cumulative population doubling; DiOC6-[3]; 3,3â²-dihexyloxacarbocyanine iodide; GA; glycidamide; HUVEC; human umbil
Keywords: BrdU; 5â²-bromo-deoxyUridine; DPP-IV; dipeptidyl-peptidase type IV; GFP; green fluorescent protein; PH; 2/3 partial hepatectomy; PFA; paraformaldehyde; RS; retrorsine; SA-β-gal; senescence-associated-β-gactosidase; YAP; yes-associated protein; Aging; L
Keywords: BMP; bone morphogenetic protein; EMT; epithelial-mesenchymal transition; MET; mesenchymal-epithelial transition; SA-β-gal; senescence β-galactosidase; SASP; senescence-associated secretory phenotype; TGF-β; transforming growth factor β;
Keywords: Chip-qPCR; chromatin immunoprecipitation quantitative polymerase chain reaction; COL1A1; collagen alpha-1(I) chain; DDR; DNA damage response; DEM; diethylmaleate; EJC; exon junction complex; ETP; etoposide; H3K4me3; trimethylation of histone H3 at Lys4; H
Keywords: Equine; Sarcoid-derived fibroblasts; BPV-1; Genomic instability; Cell cycle; ATP; SA-β-gal;
Keywords: Endothelial cell senescence; Genetic; Vascular ageing; Age-related diseases; Stem cell; Ang II; angiotensin II; APOE; apolipoprotein E; AQP1; aquaporin 1; ASS1; argininosuccinate synthase 1; CDK2; cyclin-dependent kinase 2; CDKN2A; cyclin-dependent kinase
Keywords: SA-β-gal; Senescence-associated β-galactosidase; TERT; Telomerase reverse transcriptase;
Prohibitin-2 is a novel regulator of p21WAF1/CIP1 induced by depletion of γ-glutamylcyclotransferase
Keywords: Gamma-glutamylcyclotransferase; p21WAF1/CIP1; Prohibitin-2; Protein-protein interaction; Cell cycle arrest; Cellular senescence; GGCT; gamma-glutamylcyclotransferase; p21; p21WAF1/CIP1; CDKI; cyclin-dependent kinase inhibitor; PHB; Prohibitin; ER; Estroge
Protective effects of ginsenoside Rg1 on splenocytes and thymocytes in an aging rat model induced by d-galactose
Keywords: ROS; reactive oxygen species; DNA; deoxyribonucleic acid; AGE; advanced glycation end products; MDA; malondialdehyde; SOD; superoxide dismutase; GSH; glutathione; GSSG; oxidized glutathione; SA-β-gal; senescence-associated β-galactosidase; IL-2; interle
A two-phase olive mill by-product (pâté) as a convenient source of phenolic compounds: Content, stability, and antiaging properties in cultured human fibroblasts
Keywords: Olive mill by-product; Phenolic compounds; Hydroxytyrosol; Antiaging effect; OMW; olive mill waste; VOO; virgin olive oil; EVOO; extra virgin olive oil; NHDFs; neonatal human dermal fibroblasts; DMEM; Dulbecco's modified Eagle's medium; MTS; 3-(4,5-di
Exposure of human melanocytes to UVB twice and subsequent incubation leads to cellular senescence and senescence-associated pigmentation through the prolonged p53 expression
Keywords: UVR; ultraviolet radiation; UVsen; UVB-induced senescence; SAP; senescence-associated pigmentation; SA-β-Gal; senescence-associated β-galactosidase; TPA; tetradecanoyl phorbol acetate; CT; cholera toxin; pTpT; thymine dinucleotides; HEMn; human epiderma
Gut flora-dependent metabolite Trimethylamine-N-oxide accelerates endothelial cell senescence and vascular aging through oxidative stress
Keywords: Ach; acetylcholine; ALT; alanine aminotransferase; AST; aspartate aminotransferase; BMI; body mass index; Collagen/MA; the ratio of collagen content to media area; CPDL; cumulative population doubling level; CVD; cardiovascular disease; DBP; diastolic blo
3D TECA hydrogel reduces cellular senescence and enhances fibroblasts migration in wound healing
Keywords: 3D TECA; Cellular senescence; SA-β-gal; TNF-α; Fibroblast migration;
Overexpression of Sirt1 in mesenchymal stem cells protects against bone loss in mice by FOXO3a deacetylation and oxidative stress inhibition
Keywords: ALP; alkaline phosphatase; Bmi-1; B cell-specific Moloney murine leukemia virus integration site 1; Bmi-1â/â; Bmi1 deficiency; Bmi-1+/â; Bmi-1 heterozygous; Col-I; type I collagen; Col-II; type II collagen; FOXO; Forkhead box O; GPX1; Glutathione pe
Depletion of oxaloacetate decarboxylase FAHD1 inhibits mitochondrial electron transport and induces cellular senescence in human endothelial cells
Keywords: BrdU; 5-bromo-2â²deoxy-uridine; ETC; electron transport chain; FAHD1; fumarylacetoacetate hydrolase (FAH) domain-containing protein 1; FCCP; carbonyl cyanide 4-(trifluoromethoxy) phenylhydrazone; HUVEC; human umbilical vein endothelial cells; JC-1; 5.5â
Protein kinase C downregulation induces senescence via FoxO3a inhibition in HCT116 and HEK293Â cells
Keywords: Senescence; Protein kinase C; FoxO3a; ROS; p53; p21Cip1/WAF1; CK2; protein kinase CK2; DCFDA; dichlorofluorescein diacetate; DHE; dihydroethidium; DMEM; Dulbecco's modified Eagle's media; ECL; enhanced chemiluminescence; FoxO; forkhead homeobox type O; HA
Increased chemo-sensitivity by knockdown coilin expression involved acceleration of premature cellular senescence in HeLa cells
Keywords: Cajal body; Coilin; Cisplatin; Senescence; SA-β-gal;
Tris (2-chloroethyl) phosphate induces senescence-like phenotype of hepatocytes via the p21Waf1/Cip1-Rb pathway in a p53-independent manner
Keywords: DMSO; dimethyl sulfoxide; FBS; fetal bovine serum; IL; 6 interleukin-6; MAPK; mitogen-activated protein kinase; MTT; 3-(4 5-dimethyithiazol-2-yl)-2,5-diphenyl-tetrazolium bromide; Rb; retinoblastoma; SA-β-Gal; senescence-associated β-galactosidase; SASP
Deregulation of hsa-miR-20b expression in TNF-α-induced premature senescence of human pulmonary microvascular endothelial cells
Keywords: RS; replicative senescence; CIPS; cytokine-induced premature senescence; pRB; retinoblastoma protein; TNF-α; tumor necrosis factor alpha; SA-β-gal; senescence-associated beta-galactosidase; HMVEC-Ls; human pulmonary microvascular endothelial cells; PD;
Inhibition of stress induced premature senescence in presenilin-1 mutated cells with water soluble Coenzyme Q10
Keywords: Aβ; amyloid-beta peptide; AD; Alzheimer's disease; APP; amyloid precursor protein; CoQ10; Coenzyme Q10; DCF; 2â²,7â²-dichlorofluorescein; DIC; differential interference contrast; H2DCFDA; 2â²-7â²-dichlorofluorescin diacetate; HBSS; Hank's Balanced Sa
Topical application of glycolic acid suppresses the UVB induced IL-6, IL-8, MCP-1 and COX-2 inflammation by modulating NF-κB signaling pathway in keratinocytes and mice skin
Keywords: Glycolic acid (GA); ultraviolet B (UVB); cyclooxygenase (COX)-2; interleukin (IL)-1β; monocyte chemoattractant protein (MCP-1); nuclear factor kappa B (NF-κB); AHAs; alpha hydroxy acids; COX-2; cyclooxygenase-2; GA; glycolic acid; GM-CSF; granulocyte-ma
Original ArticleNegative regulation of Sirtuin 1 by AMP-activated protein kinase promotes metformin-induced senescence in hepatocellular carcinoma xenografts
Keywords: Metformin; Sirtuin 1; AMP-activated protein kinase; Cellular senescence; Hepatocellular carcinoma; SIRT1; Sirtuin 1; AMPK; AMP-activated Protein Kinase; TIS; therapy-induced senescence; SA-β-gal; senescence-associated β-galactosidase;
Combined Inhibition of CDK4/6 and PI3K/AKT/mTOR Pathways Induces a Synergistic Anti-Tumor Effect in Malignant Pleural Mesothelioma Cells
Keywords: MPM; Malignant Pleural Mesothelioma; BAP1; BRCA1 Associated Protein 1; CDK; Cyclin-dependent kinase; RB; Retinoblastoma Protein; SA-β-GAL; Senescence Associated β-Galactosidase;
EphB2 signaling-mediated Sirt3 expression reduces MSC senescence by maintaining mitochondrial ROS homeostasis
Keywords: Eph; Ephrin receptor; Sirt; sirtuin; MnSOD; mitochondrial localized superoxide dismutase 2; UCB-MSC; umbilical cord blood derived mesenchymal stem cell; mtROS; mitochondrial reactive oxygen species; NT; non-targeting; siRNA; small interference ribose nucl
Hepatic stellate cell interferes with NK cell regulation of fibrogenesis via curcumin induced senescence of hepatic stellate cell
Keywords: Hepatic fibrosis; Natural killer cell; Hepatic stellate cell; Senescence; Granule exocytosis; 3,4-DCI; 3,4-Dichloroisocoumarin; α-SMA; α-Smooth muscle actin; CCl4; Carbon tetrachloride; CMA; Concanamycin A; DAPI; 4â², 6-Diamidino-2-phenylindole; DMEM;
Cellular senescence regulated by SWI/SNF complex subunits through p53/p21 and p16/pRB pathway
Keywords: DDR; DNA damage response; DMSO; dimethyl sulfoxide; GFP; green fluorescent protein; IP; immunoprecipitation; LC50; Lethal Concentration 50; MRT; malignant rhabdoid tumor; MSP58; 58-kDa Microspherule Protein; NC; non-specific; PI; Propidium Iodide; PVDF; p
Zinc regulates Nox1 expression through a NF-κB and mitochondrial ROS dependent mechanism to induce senescence of vascular smooth muscle cells
Keywords: ACD; actinomycin D; Ang II; angiotensin II; CHL; chloroquine; CHX; cycloheximide; Co; cobalt; Cu; copper; CVD; cardiovascular diseases; DMEM; Dulbecco's modified eagle medium; DPBS; Dulbecco's phosphate-buffered saline; EGF; epidermal growth factor; Fe; i
G protein-coupled receptor kinase 4-induced cellular senescence and its senescence-associated gene expression profiling
Keywords: GPCR; G protein-coupled receptor; GRK; G protein-coupled receptor kinases; SA-β-Gal; senescence-associated-β-galactosidase; FACS; fluorescence-activated cell sorting; CCK-8; cell counting kit-8; CDK; cyclin-dependent kinase; CKI; cyclin-dependent kinase
The ROS-mediated activation of IL-6/STAT3 signaling pathway is involved in the 27-hydroxycholesterol-induced cellular senescence in nerve cells
Keywords: 27HC; 27-hydroxycholesterol; SERM; selective estrogen receptor modulator; E2; 17β-estradiol; ROS; Reactive oxygen species; STAT3; Signal transducer and activator of transcription 3; NAC; N-acetylcysteine; SA-β-Gal; Senescence-associated b-galactosidase;
Happily (n)ever after: Aging in the context of oxidative stress, proteostasis loss and cellular senescence
Keywords: AD; Alzheimer's Disease;; AGEs; advanced glycation endproducts; ALP; autophagy-lysosome pathway; ARF; alternate reading frame; ATGs; autophagy-related proteins; BAG3; Bcl2-associated athanogene 3; Bcl-2; B-cell lymphoma 2; BrdU; 5-bromodeoxyuridine;; CMA;
MicroRNA-34a induces a senescence-like change via the down-regulation of SIRT1 and up-regulation of p53 protein in human esophageal squamous cancer cells with a wild-type p53 gene background
Keywords: EC; esophageal carcinoma; SA-β-Gal; senescence-associated β-galactosidase; SIRT1; Sirtuin1; ADR; adrmycin; PCR; polymerase chain reaction; PNUTS; phosphatase-1 nuclear targeting subunit; DMSO; dimethylsulfoxide; Esophageal squamous cancer cell; p53; miR
MicroRNA-33 promotes the replicative senescence of mouse embryonic fibroblasts by suppressing CDK6
Keywords: MicroRNA-33; Cellular senescence; CDK6; Proliferation; MEFs; Mouse Embryonic Fibroblasts; SA-β-gal; Senescence-associated β-galactosidase staining; CDK6; cyclin-dependent protein kinase 6;
ASPL-TFE3 Oncoprotein Regulates Cell Cycle Progression and Induces Cellular Senescence by Up-Regulating p21
Keywords: ASPS; alveolar soft part sarcoma; ChIP; chromatin immunoprecipitation; FACS; fluorescence-activated cell sorting; MSCs; mesenchymal stem cells; OIS; oncogene-induced senescence; SA-β-gal; senescence-associated β-galactosidase; SASP; senescence-associate
Pro-Proliferative Function of Mitochondrial Sirtuin Deacetylase SIRT3 in Human Melanoma
Keywords: cdk; cyclin-dependent kinase; SA-β-Gal; senescence-associated beta-galactosidase; SAHF; senescence-associated heterochromatin foci; shNS; nonspecific shRNA; shRNA; short hairpin RNA; SIRTs; sirtuins; TMAs; tissue microarrays;
Protective effect of different flavonoids against endothelial senescence via NLRP3 inflammasome
Keywords: Endothelial senescence; Flavonoids; High glucose; NLRP3 inflammasome; Reactive oxygen species; Quercetin (PubChem CID: 5280343); Puerarin (PubChem CID: 5281807); Troxerutin (PubChem CID: 5486699); ASC; apoptotic speck-like protein containing a CARD domain
Sustained activation of ADP/P2ry12 signaling induces SMC senescence contributing to thoracic aortic aneurysm/dissection
Keywords: TAAD; thoracic aortic aneurysm/dissection; SMC; smooth muscle cell; ECM; extracellular matrix; SA-β-gal; senescence-associated β-galactosidase; ADP; adenosine diphosphate; P2ry12; P2Y G protein-coupled receptor 12; DAMPs; damage-associated molecular pat
miR-29c-3p promotes senescence of human mesenchymal stem cells by targeting CNOT6 through p53-p21 and p16-pRB pathways
Keywords: hMSCs; human mesenchymal stem cells; SA-β-gal; senescence-associated-β-galactosidase; ANOVA; analysis of variance; CCK-8; Cell Counting Kit-8; WB; Western blot; IF; immunofluorescence; Replicative senescence; Mesenchymal stem cell; MicroRNA; Tissue engi
Different effects of resveratrol on early and late passage mesenchymal stem cells through β-catenin regulation
Keywords: SIRT1; Resveratrol; Mesenchymal stem cells; Cellular senescence; β-catenin; CFU-F; colony-forming unit fibroblast; EP-MSC; early passage mesenchymal stem cell; DAPI; 4â²,6-diamidino-2-phenylindole; DMEM-LG; Dulbecco's modified Eagle medium, low glucose;
Regulation and function of Myb-binding protein 1A (MYBBP1A) in cellular senescence and pathogenesis of head and neck cancer
Keywords: DNA damage; Stress response; Treatment failure; Cancer; MYBBP1A; Myb-binding protein 1A; OPSCC; oropharyngeal squamous cell carcinoma; HNSCC; head and neck squamous cell carcinoma; SA-β-Gal; senescence-associated β-galactosidase; SAHF; senescence-associ