3D TECA hydrogel reduces cellular senescence and enhances fibroblasts migration in wound healing

Three dimensional hydrogel containing titrated extract of Centella asiatica was prepared following Trojan et al. (2005) with slight medication. The hydrogel was cultured with periodontal ligament fibroblasts which are triggered with TNF-α, then the senescence marker of fibroblasts was measured. Migration of fibroblasts using in vitro wound healing assay was also evaluated. 53