کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10900581 | 1084653 | 2005 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
4â²-O-Alkyaloenin derivatives and their sulfates directed toward overcoming multidrug resistance in tumor cells
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موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
تحقیقات سرطان
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
The cytotoxic effects on HCT 116, Hep G2 and HCT 116/VCR 100-1-1 cell lines of synthetic 4â²-O-alkylaloenins (2-17), 4â²-O-benzylaloenin (18) and 4â²-O-allylaloenin (19) were examined by MTT assay, and compared with that of aloenin (1) isolated from Aloe arborescens Mill. Var. natalensis Berger which showed no marked effect (IC50 value: >100 μM). The cytotoxic effects of 4â²-O-alkylaloenin sulfates (21-29) were also examined on the same cell lines. The introduction of a longer alkyl group at the O-4â² position of 1 resulted in a higher cytotoxic action on HCT 116 and Hep G2 cells. Among 4â²-O-alkylaloenins 2-17, 4â²-O-tetradecylaloenin 14 was the most cytotoxic to both on HCT 116 cells (IC50 value: 5.3±2.3 μM) and Hep G2 cells (IC50 value: 4.0±0.6 μM). Also among 4â²-O-alkylaloenin sulfates 21-29, 4â²-O-dodecylaloenin sulfate 29 was the most cytotoxic to both on HCT 116 (IC50 value: 4.8±0.2 μM) and Hep G2 cells (IC50 value: 4.0±0.5 μM). 4â²-O-Alkylaloenins 7-14 and 4â²-O-alkylaloenin sulfates 24-29 were also cytotoxic to Hep G2 and HCT 116/VCR 100-1-1 cell lines, which overexpress P-glycoprotein, as well as HCT 116 cell lines which scarcely express it.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Cancer Letters - Volume 218, Issue 1, 31 January 2005, Pages 15-20
Journal: Cancer Letters - Volume 218, Issue 1, 31 January 2005, Pages 15-20
نویسندگان
Guang-zhu Jin, Hong-Ji Quan, Jyunichi Koyanagi, Kazuhiro Takeuchi, Yoshihiko Miura, Fusao Komada, Setsuo Saito,