کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10909553 | 1087915 | 2005 | 11 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Coexpression and regulation of the FGF-2 and FGF antisense genes in leukemic cells
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
تحقیقات سرطان
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Coexpression and regulation of the FGF-2 and FGF antisense genes in leukemic cells Coexpression and regulation of the FGF-2 and FGF antisense genes in leukemic cells](/preview/png/10909553.png)
چکیده انگلیسی
Fibroblast growth factor-2 (FGF-2) is a growth and survival factor whose expression is elevated in many hematopoietic malignancies. A natural antisense RNA (FGF-AS) has been implicated in the posttranscriptional regulation of FGF-2 mRNA expression. We demonstrate for the first time that FGF sense and antisense RNAs are coordinately expressed and translated in hematopoietic cells and tissues. Cytokine stimulation of growth-arrested K562 cells elicited a rapid transient increase in FGF-AS mRNA expression followed by a slower but sustained increase in FGF-2 mRNA. This was accompanied by a marked increase in the expression and nuclear translocation of FGF-2 and the FGF-AS encoded protein, GFG/NUDT6. These findings suggest a role for both FGF-2 and GFG proteins in the cell survival and proliferation of lymphoid and myeloid tumor cells.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Leukemia Research - Volume 29, Issue 4, April 2005, Pages 423-433
Journal: Leukemia Research - Volume 29, Issue 4, April 2005, Pages 423-433
نویسندگان
Mark Baguma-Nibasheka, Audrey W. Li, Mohammed S. Osman, Laurette Geldenhuys, Alan G. Casson, Catherine K.L. Too, Paul R. Murphy,