کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10911670 | 1088389 | 2005 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Expression of endoplasmic reticulum molecular chaperone Grp78 in human lung cancer and its clinical significance
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کلمات کلیدی
ATF4GRP78GRPUPRCeA - CEAcarcinoembryonic antigen - آنتی ژن carcinoembryonicimmunohistochemical - ایمونوهیستوشیمیIHC - ایمونوهیستوشیمیimmunohistochemical analysis - تجزیه و تحلیل ایمونوهیستوشیمیLung cancer - سرطان ریهNSCLC - سرطان ریوی غیر سلول کوچکNon-small cell lung cancer - سرطان غیر سلول کوچک ریهendoplasmic reticulum - شبکه آندوپلاسمی Prognostic factor - عامل پیش آگهیactivating transcription factor 4 - فعال کردن عامل رونویسی 4Unfolded protein response - پاسخ پروتئین آشکارglucose-regulated protein - پروتئین تنظیم شده با گلوکز
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
تحقیقات سرطان
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Expression of endoplasmic reticulum molecular chaperone Grp78 in human lung cancer and its clinical significance Expression of endoplasmic reticulum molecular chaperone Grp78 in human lung cancer and its clinical significance](/preview/png/10911670.png)
چکیده انگلیسی
All eukaryotic cells respond to the accumulation of unfolded proteins in the endoplasmic reticulum (ER) by signaling an adaptive pathway termed the unfolded protein response (UPR). Glucose-regulated protein (Grp) 78 is a molecular chaperone involved in the UPR. The aim of this study was to detect Grp78 expression in lung cancer using immunohistochemical (IHC) staining, and also to evaluate the relationship between the Grp78 expression level and the prognosis of patients with lung cancer. We used immunohistochemistry to analyze the protein expression of Grp78 in paraffin-embedded tumor samples from 132 well-characterized lung cancer patients and compared the expression level of Grp78, clinical variables and survival outcome. A positive expression of Grp78 was detected in the cytoplasm of tumor cells in 88 of the 132 patients (66.7%) with lung cancer. No significant difference was observed between the Grp78 expression and the gender, age at operation, histological type, pathologic stage, pathologic T status, and pathologic N status. Lung cancer patients with a positive Grp78 expression tended to show a better prognosis than those with a negative Grp78 expression. In addition, a multivariate analysis of the clinicopathologic characteristics of lung cancer indicated a positive expression of Grp78 to be a significant factor for predicting a favorable prognosis (p < 0.001, risk ratio = 2.35). A positive expression of Grp78 may thus be a useful marker for predicting a favorable prognosis in patients undergoing a resection of lung cancer. The ER stress pathway mediated by Grp78 may therefore be responsible for controlling the growth of lung cancer cells.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Lung Cancer - Volume 49, Issue 1, July 2005, Pages 55-62
Journal: Lung Cancer - Volume 49, Issue 1, July 2005, Pages 55-62
نویسندگان
Hidetaka Uramoto, Kenji Sugio, Tsunehiro Oyama, Shoji Nakata, Kenji Ono, Takashi Yoshimastu, Masaru Morita, Kosei Yasumoto,