Keywords: فعال کردن عامل رونویسی 4; Hydrogen sulfide; Gasotransmitter; Sulfhydration; Neurodegeneration; Oxidative stress; Antioxidants; 3-MST; 3-mercaptopyruvate sulfurtransferase; 4-HNE; 4-hydroxynonenal; 6-OHDA; 6-hydroxydopamine; Aβ; β-Îmyloid; AD; Alzheimer's disease; ALS; Amyotro
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Keywords: فعال کردن عامل رونویسی 4; Runx2; Runt-related transcription factor-2; Osx; Oster; Alp; alkaline phosphatase; Col1a1; collagen type I alpha 1; Atf4; activating transcription factor 4; LDHA; lactate dehydrogenase A; PDK1; pyruvate dehydrogenase kinase 1; TCA; tricarboxylic acid; FND
Keywords: فعال کردن عامل رونویسی 4; HIV; human immunodeficiency virus; SA; South Africa; NOx; oxides of nitrogen; BW; birthweight; Nrf2; nuclear factor (erythroid-derived 2)-like 2; Keap1; kelch-like ECH-associated protein 1; mi-RNA; microRNA; NO; nitrites/nitrates; MDA; malondialdehyde; ER
Keywords: فعال کردن عامل رونویسی 4; 18S; 18S ribosomal RNA; 36B4; acidic ribosomal protein 36B4; Acc1; acetyl-CoA carboxylase α; Acox1; acyl-CoA oxidase 1; Apob; apolipoprotein B; ARE; antioxidant response element; AST; aspartate aminotransferase; ALT; alanine aminotransferase; ATF4; activ
Keywords: فعال کردن عامل رونویسی 4; ATF4; activating transcription factor 4; ATF6α; activating transcription factor 6α; BIP; binding immunoglobulin protein; C/EBPδ; CCAAT-enhancer-binding protein delta; CSC; cancer stem cell; ER; endoplasmic reticulum; IRE1α; inositol-requiring enzyme-1
Keywords: فعال کردن عامل رونویسی 4; 3-MC; 3-methylcholanthrene; Ah; aryl hydrocarbon; AhE; aryl hydrocarbon receptor; AP-1; activator protein-1; ARE; antioxidant response element; ATF4; activating transcription factor 4; β-NF; β-naphthoflavone; β-NF-RE; β-NF-responsive element; β-TRCP;
Keywords: فعال کردن عامل رونویسی 4; Atf4; activating transcription factor 4; BMS; basso mouse scale; Chop; CCAAT-enhancer-binding protein homologous protein; EAE; experimental autoimmune encephalomyelitis; ERSR; endoplasmic reticulum stress response; GO; gene ontology; MS; multiple sclerosi
Keywords: فعال کردن عامل رونویسی 4; AD; Alzheimer's disease; BBB; blood brain barrier; RAGE; Receptor for Advanced Glycation End products; AGE; advanced glycation end products; IL1β; interleukin 1 beta; Aβ; amyloid beta; TNF â;  tumor necrosis factor alpha; TGFβ; transforming growth
Keywords: فعال کردن عامل رونویسی 4; 2DG; 2-deoxyglucose; 3MA; 3-methyl adenine; 4E-BP1; Eukaryotic translation initiation factor 4E-binding protein 1; AICAR; 5-aminoimidazole-4-carboxamide ribonucleotide; AMPK; AMP activated protein kinase; ATF4; Activating transcription factor 4; Baf B1; B
27-hydroxycholesterol: A novel player in molecular carcinogenesis of breast and prostate cancer
Keywords: فعال کردن عامل رونویسی 4; 27-OHC; 27-hydroxycholesterol; ADT; androgen deprivation therapy; AR; androgen receptor; ATF4; Activating Transcription Factor 4; ATF6; Activating Transcription Factor 6; C/EBP; CCAAT / Enhancer binding proteins; CHOP; C/EBP homologous protein; CIP2A; can
Keywords: فعال کردن عامل رونویسی 4; 15-E2-IsoLG; isolevuglandin E2; 4-HNE; 4-hydroxy-2-nonenal; α-SMA; alpha Smooth Muscle Actin; ANOVA; analysis of variance; ATF4; Activating transcription factor 4; BiP; Immunoglobulin heavy chain binding protein; BrdU; 5-Bromo-2-Deoxyuridine; carboxy-DCF
Keywords: فعال کردن عامل رونویسی 4; eIF2α; eukaryotic translation initiation factor 2 alpha; ER; endoplasmic reticulum; CHOP; C/EBP homologous protein; RANKL; receptor activator of nuclear factor kappa-B ligand; M-CSF; macrophage-colony stimulating factor; TRAP; tartrate resistant acid pho
Keywords: فعال کردن عامل رونویسی 4; 2-AG; 2-arachidonoylglycerol; ALK; anaplastic lymphoma kinase; ATF-4; activating transcription factor 4; CB1; cannabinoid CB1 receptor; CB2; cannabinoid CB2 receptor; CBD; cannabidiol; CHOP; C/EBP homologous protein; EGFR; epidermal growth factor receptor
Keywords: فعال کردن عامل رونویسی 4; Muscle mass; Glycine; Nutrition; Calorie restriction; Fat mass; ALA; alanine; Atf4; activating transcription factor 4; AUC; area under the curve; Bnip3; BCL2/adenovirus E1B interacting protein 3; Ccl2; chemokine(C-C motif) ligand 2; Ccl5; chemokine(C-
Keywords: فعال کردن عامل رونویسی 4; αKG; 2-oxoglutarate; AMPK; AMP-activated protein kinase; ATF4; activating transcription factor 4; DDR; DNA damage response; DMOG; dimethyloxaloylglycine; eEF2; eukaryotic elongation factor 2; EGFR; epidermal growth factor receptor; HCLK2; Caenorhabditis
Keywords: فعال کردن عامل رونویسی 4; CRP; C-reactive protein; HDL; high density lipoprotein; LDL; low density lipoprotein; PPARγ; peroxisome proliferator activated receptor-γ; DPP-4; dipeptidyl peptidase-4; GLP-1; glucagon like peptide-1; TRIB3; tribbles homolog 3; ATF-4; activating transc
Keywords: فعال کردن عامل رونویسی 4; activating transcription factor 4; general control nonderepressible 2; leucine; mammalian/mechanistic target of rapamycin complex 1; tomatidine; ursolic acid;
Keywords: فعال کردن عامل رونویسی 4; AKT; protein kinase B; ATF4; activating transcription factor 4; cAMP; cyclic adenosine monophosphate; CCL5; (C-C motif) ligand 5; CNS; central nervous system; 4EBP1; 4E (elF4E) binding protein; ECM; extracellular matrix; ERK; p44/p42 extracellular signal-
Keywords: فعال کردن عامل رونویسی 4; ADI; acceptable daily intake; Apaf-1; apoptotic protease activating factor-1; ATF4; activating transcription factor 4; CHOP; C/EBP-homologous protein; eIF2α; eukaryotic initiation factor 2 alpha; ER; endoplasmic reticulum; G; ghrelin; GH; growth hormone;
Keywords: فعال کردن عامل رونویسی 4; Lysosome-associated membrane protein-2; Autophagy; Diabetes; Obesity; Lysosome; ATF4; activating transcription factor 4; ACO; acyl-CoA oxidase; BAT; brown adipose tissue; Cidea; cell death-inducing DNA fragmentation factor-α-like effector A; FGF21; fibro
Keywords: فعال کردن عامل رونویسی 4; ACTB; beta-actin; ATF4; activating transcription factor 4; BGLAP; osteocalcin; COL1A1; collagen type I alpha 1; FN1; fibronectin; IBSP; bone sialoprotein 2; IFN-γ; interferon-γ; IL; interleukin; RUNX2; runt-related transcription factor 2; SATB2; special
Keywords: فعال کردن عامل رونویسی 4; Alanine aminotransferase 2; Alanine aminotransferase 1; Activating transcription factor 4; Amino acid deprivation; ER stress; Gene knock-down;
Keywords: فعال کردن عامل رونویسی 4; ASK1; apoptosis signal-regulating kinase 1; ATF4; activating transcription factor 4; ATF6; activating transcription factor 6; Bcl-2; B-cell lymphoma 2; BiP; binding immunoglobulin protein; bZIP; basic leucine zipper; CDK; cyclin-dependent kinase; CDKI; CD
Keywords: فعال کردن عامل رونویسی 4; ACAA2; 3-oxoacyl-CoA thiolase; ADIPOR; adiponectin receptor; AF1,2; activation function 1,2; AMPK; AMP-activated protein kinase; ATF4; activating transcription factor 4; ATGL; adipose triglyceride lipase; CaMK; calcium/calmodulin-dependent kinase; CD36; f
Loss of NRF-2 and PGC-1α genes leads to retinal pigment epithelium damage resembling dry age-related macular degeneration
Keywords: فعال کردن عامل رونویسی 4; ER; endoplasmic reticulum; AMD; age-related macular degeneration; RPE; retinal pigment epithelium; PUFAs; polyunsaturated fatty acids; ROS; reactive oxygen species; NRF-2; nuclear factor-erythroid 2-related factor-2; ARE; antioxidant response element; Kea
Canonical and non-canonical mechanisms of Nrf2 activation
Keywords: فعال کردن عامل رونویسی 4; AhR; aryl hydrocarbon receptor; ARNT; aryl hydrocarbon receptor nuclear translocator; ATF4; activating transcription factor 4; Atg5; autophagy protein 5; Atg7; autophagy protein 7; Bach; BTB and CNC homology; CBP; CREB binding protein; CHD6; chromodomain-
RANKL/OPG system regulation by endogenous PTH and PTH1R/ATF4 axis in bone: Implications for bone accrual and strength in growing rats with mild uremia
Keywords: فعال کردن عامل رونویسی 4; RANKL/OPG system; Parathyroid hormone; PTH1R/ATF4 pathway; Mild chronic kidney disease; Growing rats; ATF4; activating transcription factor 4; CKD; chronic kidney disease; CKD-MBD; chronic kidney disease-mineral bone disorder; OPG; osteoprotegerin; PT
Selenium unmasks protective iron armor: A possible defense against cutaneous inflammation and cancer
Keywords: فعال کردن عامل رونویسی 4; GPX4; Glutathione Peroxidase 4; System XC; Cystine/Glutamate Antiporter-System XC; TNFα; Tumor necrosis factor alpha; VEGF; Vascular endothelial growth factor; S1P; Sphingosine-1 phosphate; IL-22; Interleukin-22; Trx1; Thioredoxin; Txnrd1; Thioredoxin re
Bicuculline Reverts the Neuroprotective Effects of Meloxicam in an Oxygen and Glucose Deprivation (OGD) Model of Organotypic Hippocampal Slice Cultures
Keywords: فعال کردن عامل رونویسی 4; AMPA; α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid; ATF4; activating transcription factor 4; BIC; OGD 30 min followed by 24â¯h of normoxic conditions, both of them in the presence of bicuculline; CA1; Cornu ammonis 1; CCD; charge-coupled device;
Oxidants produced by methylglyoxal-modified collagen trigger ER stress and apoptosis in skin fibroblasts
Keywords: فعال کردن عامل رونویسی 4; AGE; Advanced glycation end product; ATF4; Activating transcription factor 4; BID; BH3 interacting-domain death agonist; CHOP; CCAAT-enhancer-binding protein homologous protein; COL1A1; Collagen type I α1-chain; DAPI; 4',6-diamidino-2-phenylindole; ECM;
γ-Taxilin temporally regulates centrosome disjunction in a Nek2A-dependent manner
Keywords: فعال کردن عامل رونویسی 4; C-Nap1; centrosomal never in mitosis A-related kinase-associated protein 1; Nek2; never in mitosis A-related kinase 2; APC/C; anaphase promoting complex/cyclosome; ER; endoplasmic reticulum; PCR; polymerase chain reaction; siRNA; small interfering RNA; PB
Activation of Serine One-Carbon Metabolism by Calcineurin Aβ1 Reduces Myocardial Hypertrophy and Improves Ventricular Function
Keywords: فعال کردن عامل رونویسی 4; cardiac function; cell signaling; hypertrophy; metabolism; ATF4; activating transcription factor 4; BSO; L-buthionine-sulfoximine; GSH; reduced glutathione; LVEF; left ventricular ejection fraction; LVMi; left ventricular mass index; mTOR; mechanistic tar
Neuroprotective effect of He-Ying-Qing-Re formula on retinal ganglion cell in diabetic retinopathy
Keywords: فعال کردن عامل رونویسی 4; HF; He-Ying-Qing-Re Formula; RGC; Retinal ganglion cell; DR; Diabetic retinopathy; STZ; Streptozotocin; GCL; Ganglion cell layer; INL; Inner nuclear layer; IPL; Inner plexiform layer; H2O2; Hydrogen peroxide; ROS; Reactive oxygen species; BRB; Blood-retin
ER stress and cancer: The FOXO forkhead transcription factor link
Keywords: فعال کردن عامل رونویسی 4; Endoplasmic reticulum; ER stress; Cancer; FOXO; Forkhead transcription factors; Unfolded protein response; AKT; Protein Kinase B; AKT1; Protein Kinase B Alpha; AMPK; AMP-activated protein kinase; ASK1; Apoptosis Signal Regulated Kinase 1; ATF4; Activating
Selective alteration of adult hippocampal neurogenesis and impaired spatial pattern separation performance in the RSK2-deficient mouse model of Coffin-Lowry syndrome
Keywords: فعال کردن عامل رونویسی 4; AMPA; aminoâ3âhydroxyâ5âmethylâ4âisoxazolepropionic acid; ATF4; activating transcription factor 4; BAD; Bcl-2-associated death promoter; CBP; CREB-binding protein; CLS; Coffin-Lowry syndrome; CREB; cAMP-response element binding protein; DG; de
Drosophila as a model for ageing
Keywords: فعال کردن عامل رونویسی 4; 4EBP; translation initiation factor 4E binding protein; AMPK; AMP activated protein kinase; AOP; anterior open; ATF4; activating transcription factor 4; CHOP; C/EBP homologous protein; CR; calorie restriction; DR; dietary restriction; eIF; eukaryotic tran
Aberrant subcellular localization of SQSTM1/p62 contributes to increased vulnerability to proteotoxic stress recovery in Huntington's disease
Keywords: فعال کردن عامل رونویسی 4; ATF4; activating transcription factor 4; BSA; bovine serum albumin; CHX; cycloheximide; CQ; hydroxychloroquine; HD; Huntington's disease; HDAC6; histone deacetylase 6; Htt; huntingtin; mHtt; mutant huntingtin; Lamp1; lysosomal associated membrane protein
Guanabenz promotes neuronal survival via enhancement of ATF4 and parkin expression in models of Parkinson disease
Keywords: فعال کردن عامل رونویسی 4; 6-OHDA; 6-hydroxydopamine; ATF4; activating transcription factor 4; CPT; camptothecin; GA; guanabenz acetate; MPP+; 1-methyl-4-phenylpyridinium; PD; Parkinson's disease; SN; substantia nigra; TH; tyrosine hydroxylase; Parkinson's disease; ATF4; Parkin; Gu
ERK1/2 activated PHLPP1 induces skeletal muscle ER stress through the inhibition of a novel substrate AMPK
Keywords: فعال کردن عامل رونویسی 4; 2-NBDG; 2-(N-[7-nitrobenz-2-oxa-1,3-diazol-4-yl]amino)-2-deoxyglucose; AICAR; 5-aminoimidazole-4-carboxamide-1-b-d-ribofuranoside; AMPK; AMP-activated protein kinase; AS160; Akt Substrate of 160â¯kDa; ATF4; Activating Transcription Factor 4; AUC; area un
Costunolide increases osteoblast differentiation via ATF4-dependent HO-1 expression in C3H10T1/2 cells
Keywords: فعال کردن عامل رونویسی 4; Runx2; runt-related transcription factor 2; ALP; alkaline phosphatase; OC; osteocalcin; ATF4; activating transcription factor 4; HO-1; heme oxygenase-1; SnPP; Sn(IV) protoporphyrin IX dichloride; Costunolide; ATF4; HO-1; SnPP; Osteogenesis;
Ancestral benzo[a]pyrene exposure affects bone integrity in F3 adult fish (Oryzias latipes)
Keywords: فعال کردن عامل رونویسی 4; AcvR1b; activating receptor type 1b; ALP; alkaline phosphatase; APC; adenomatous polyposis coli; ATF4; activating transcription factor 4; BaP; benzo[a]pyrene; BMD; bone mineral density; BMP2; bone morphogenetic protein 2; Col2a1b; collagen 2a1b; Col10; co
Simultaneous targeting PI3K and PERK pathways promotes cell death and improves the clinical prognosis in esophageal squamous carcinoma
Keywords: فعال کردن عامل رونویسی 4; ESCC; PI3K; mTOR; PERK; LY294002; GSK2656157; Activating transcription factor 4; ATF4; Esophageal adenocarcinoma; EAC; Esophageal squamous cell carcinoma; ESCC; eukaryotic translation initiation factor 2-alpha; elF2α; phosphorylated elF2α; p-elF2α; Ove
Metformin triggers apoptosis in PEL cells and alters bortezomib-induced Unfolded Protein Response increasing its cytotoxicity and inhibiting KSHV lytic cycle activation
Keywords: فعال کردن عامل رونویسی 4; AMPK; AMP-activated protein kinase; ATF4; Activating Transcription Factor 4; ATF6; Activating Transcription Factor 6; BAF; Bafilomycin A1; BiP (GRP78); Binding immunoglobulin Protein (78Â kDa glucose regulated protein); BZ; bortezomib; CHOP; C/EBP-Homolog
Molecular cloning and characterization of unfolded protein response genes from large yellow croaker (Larimichthys crocea) and their expression in response to dietary fatty acids
Keywords: فعال کردن عامل رونویسی 4; ATF6; activating transcription factor-6; ATF4; activating transcription factor 4; BiP/GRP78; immunoglobulin heavy chain binding protein/glucose-regulated protein 78; CHOP; C/EBP homologous protein; ER; endoplasmic reticulum; ERAD; ER-associated protein de
Original ArticleGRP78 inhibition enhances ATF4-induced cell death by the deubiquitination and stabilization of CHOP in human osteosarcoma
Keywords: فعال کردن عامل رونویسی 4; Osteosarcoma; ATF4; GRP78; CHOP; Ubiquitination; ATF4; activating transcription factor 4; BTZ; bortezomib; CFDA SE; carboxyfluorescein diacetate succinimidyl ester; CHOP; CCAAT/enhancer-binding protein (C/EBP) homologous protein; CHX; cycloheximide; DDIT3
Research PaperLong-term protective effects of AAV9-mesencephalic astrocyte-derived neurotrophic factor gene transfer in parkinsonian rats
Keywords: فعال کردن عامل رونویسی 4; 6-OHDA; 6-hydroxydopamine; AAV; adeno-associated virus; ATF4; activating transcription factor 4; ATF6α; activating transcription factor 6α; Bip; binding immunoglobulin protein; CDNF; cerebral dopamine neurotrophic factor; CR3; complement receptor 3; CHO
A new role of GCN2 in the nucleolus
Keywords: فعال کردن عامل رونویسی 4; GCN2; Amino acid starvation; Nucleolus; p53; RNA polymerase III; ARPP P0; acidic ribosomal phosphoprotein P0; ATF4; activating transcription factor 4; BRF1; B-related factor 1; eIF2α; eukaryotic initiation factor 2 alpha subunit; FC; fibrillar center; GA
Intraventricular administration of Tenebrio molitor larvae extract regulates food intake and body weight in mice with high-fat diet-induced obesity
Keywords: فعال کردن عامل رونویسی 4; Appetite; Diet-induced obesity; Hypothalamus; Neuropeptide; Tenebrio molitor larvae; AgRP; agouti-related peptide; ATF4; activating transcription factor 4; CHOP; c/EBP-homologous protein; eIF2α; α subunit of eukaryotic translation initiation factor 2; E
Rifampicin-induced injury in HepG2 cells is alleviated by TUDCA via increasing bile acid transporters expression and enhancing the Nrf2-mediated adaptive response
Keywords: فعال کردن عامل رونویسی 4; RFP; rifampicin; TUDCA; tauroursodeoxycholic acid; Nrf2; nuclear factor erythroid 2-related factor; DILI; drug-induced liver injury; ALF; acute liver failure; TB; tuberculosis; INH; isoniazid; GSH; glutathione; BAs; bile acids; ER; endoplasmic reticulum;
Human Keratinocyte Differentiation Requires Translational Control by the eIF2α Kinase GCN2
Keywords: فعال کردن عامل رونویسی 4; ATF4; activating transcription factor 4; CHOP; C/EBP homologous protein; eIF2α; eukaryotic initiation factor 2 alpha; eIF2α-P; phosphorylated eukaryotic initiation factor 2; ER; endoplasmic reticulum; GADD34; growth arrest and DNA damage protein 34; GCN