کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5588854 1404585 2016 11 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Amino Acid Sensing in Skeletal Muscle
ترجمه فارسی عنوان
آمینو اسید در عضله اسکلتی
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی علوم غدد
چکیده انگلیسی
Aging impairs skeletal muscle protein synthesis, leading to muscle weakness and atrophy. However, the underlying molecular mechanisms remain poorly understood. Here, we review evidence that mammalian/mechanistic target of rapamycin complex 1 (mTORC1)-mediated and activating transcription factor 4 (ATF4)-mediated amino acid (AA) sensing pathways, triggered by impaired AA delivery to aged skeletal muscle, may play important roles in skeletal muscle aging. Interventions that alleviate age-related impairments in muscle protein synthesis, strength, and/or muscle mass appear to do so by reversing age-related changes in skeletal muscle AA delivery, mTORC1 activity, and/or ATF4 activity. An improved understanding of the mechanisms and roles of AA sensing pathways in skeletal muscle may lead to evidence-based strategies to attenuate sarcopenia.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Trends in Endocrinology & Metabolism - Volume 27, Issue 11, November 2016, Pages 796-806
نویسندگان
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