کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10914718 1088808 2013 16 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Genetically engineered mouse models of prostate cancer
ترجمه فارسی عنوان
مدل موش های تولید شده از لحاظ ژنتیکی مهندسی سرطان پروستات
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی تحقیقات سرطان
چکیده انگلیسی
Despite major improvement in treatment of early stage localised prostate cancer, the distinction between indolent tumors and those that will become aggressive, as well as the lack of efficient therapies of advanced prostate cancer, remain major health problems. Genetically engineered mice (GEM) have been extensively used to investigate the molecular and cellular mechanisms underlying prostate tumor initiation and progression, and to evaluate new therapies. Moreover, the recent development of conditional somatic mutagenesis in the mouse prostate offers the possibility to generate new models that more faithfully reproduce the human disease, and thus should contribute to improve diagnosis and treatments. The strengths and weaknesses of various models will be discussed, as well as future opportunities.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Molecular Oncology - Volume 7, Issue 2, April 2013, Pages 190-205
نویسندگان
, ,