کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10915460 | 1090064 | 2005 | 14 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
TWIST is Expressed in Human Gliomas, Promotes Invasion
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کلمات کلیدی
HGFIGFFBSbHLHGBMGliosarcoma - gliosarcomaH&E - H & Ebasic helix-loop-helix - اسلحه پایه حلقه ایOncogene - انکوژنInvasion - تهاجمBrain tumor - تومور مغزیCNS - دستگاه عصبی مرکزیCancer - سرطانfetal bovine serum - سرم جنین گاوcentral nervous system - سیستم عصبی مرکزیHepatocyte growth factor - عامل رشد هپاتوسیتInsulin-like growth factor - فاکتور رشد مانند انسولینNeuron - نورونGlioblastoma - گلیوبلاستوما
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
تحقیقات سرطان
پیش نمایش صفحه اول مقاله
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چکیده انگلیسی
TWIST is a basic helix-loop-helix (bHLH) transcription factor that regulates mesodermal development, promotes tumor cell metastasis, and, in response to cytotoxic stress, enhances cell survival. Our screen for bHLH gene expression in rat C6 glioma revealed TWIST. To delineate a possible oncogenic role for TWIST in the human central nervous system (CNS), we analyzed TWIST message, protein expression in gliomas, normal brain. TWIST was detected in the large majority of human glioma-derived cell lines, human gliomas examined. Increased TWIST mRNA levels were associated with the highest grade gliomas, increased TWIST expression accompanied transition from low grade to high grade in vivo, suggesting a role for TWIST in promoting malignant progression. In accord, elevated TWIST mRNA abundance preceded the spontaneous malignant transformation of cultured mouse astrocytes hemizygous for p53. Overexpression of TWIST protein in a human glioma cell line significantly enhanced tumor cell invasion, a hallmark of high-grade gliomas. These findings support roles for TWIST both in early glial tumorigenesis, subsequent malignant progression. TWIST was also expressed in embryonic, fetal human brain, in neurons, but not glia, of mature brain, indicating that, in gliomas, TWIST may promote the functions also critical for CNS development or normal neuronal physiology.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neoplasia - Volume 7, Issue 9, September 2005, Pages 824-837
Journal: Neoplasia - Volume 7, Issue 9, September 2005, Pages 824-837
نویسندگان
Maria C. Elias, Kathleen R. Tozer, John R. Silber, Svetlana Mikheeva, Mei Deng, Richard S. Morrison, Thomas C. Manning, Daniel L. Silbergeld, Carlotta A. Glackin, Thomas A. Reh, Robert C. Rostomily,