Extracellular acidosis impairs P2Y receptor-mediated Ca2+ signalling and migration of microglia

- External acidosis affects P2Y receptor dependent Ca2+ signalling in microglia.
- External acidosis strongly reduced P2Y receptor dependent Ca2+ influx.
- There was little impact of external acidosis on P2Y receptor dependent Ca2+ release.
- Extracellular acidosis inhibited P2Y receptor induced but not basal migration.