Electrical coupling between the human serotonin transporter and voltage-gated Ca2+ channels

- S(+)MDMA (ecstasy) and 5HT (serotonin) induce Ca2+ mobilization in cultured muscle cells expressing hSERT.
- hSERT-mediated depolarization activates CaV1.3 but not CaV2.2 in HEK293 cells.
- The electrical coupling between hSERT and CaV1.3 takes place at physiological concentrations of 5HT.
- hSERT-mediated depolarization activates voltage-gated calcium channels.