Mitochondrial regulation of CRAC channel-driven cellular responses

One widespread and conserved Ca2+ entry pathway in eukaryotic cells is the store-operated CRAC channel and Ca2+ entry through these channels activates a disparate array of cellular responses. Under physiological conditions, mitochondria are important regulators of CRAC channel gating. Through these actions, mitochondria help control a range of spatially and temporally distinct CRAC channel-driven responses including enzyme activation, secretion, intercellular communication through paracrine signals and gene expression.