کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10931446 1093639 2015 36 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Recent advances in the study of zebrafish extracellular matrix proteins
ترجمه فارسی عنوان
پیشرفت های اخیر در مطالعه پروتئین های ماتریکس خارج سلولی ماهی قزل آلا
کلمات کلیدی
ماتریکس غیر سلولی، ماهی قزل آلا، فیبرنکتین، لامینین، کلاژن، مورفولوژی،
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیولوژی سلول
چکیده انگلیسی
The zebrafish extracellular matrix (ECM) is a dynamic and pleomorphic structure consisting of numerous proteins that together regulate a variety of cellular and morphogenetic events beginning as early as gastrulation. The zebrafish genome encodes a similar complement of ECM proteins as found in other vertebrate organisms including glycoproteins, fibrous proteins, proteoglycans, glycosaminoglycans, and interacting or modifying proteins such as integrins and matrix metalloproteinases. As a genetic model system combined with its amenability to high-resolution microscopic imaging, the zebrafish allows interrogation of ECM protein structure and function in both the embryo and adult. Accumulating data have identified important roles for zebrafish ECM proteins in processes as diverse as cell polarity, migration, tissue mechanics, organ laterality, muscle contraction, and regeneration. In this review, I highlight recently published data on these topics that demonstrate how the ECM proteins fibronectin, laminin, and collagen contribute to zebrafish development and adult homeostasis.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Developmental Biology - Volume 401, Issue 1, 1 May 2015, Pages 110-121
نویسندگان
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