Antisense noncoding RNA promoter regulates the timing of de novo methylation of an imprinting control region

► Addressed the mechanisms that establish epigenetic marks of imprinting control regions (ICR). ► Genetic signatures establish and maintain differential epigenetic marks at Kcnq1 ICR. ► The Kcnq1ot1 promoter establishes epigenetic memory at Kcnq1 ICR during male germline.