Lrp5 and Lrp6 redundantly control skeletal development in the mouse embryo

► Single deletion of either Lrp5 or Lrp6 had little effect on embryonic skeleton. ► Double deletion of Lrp5 and Lrp6 in limb mesenchyme phenocopied β-catenin deletion. ► Deletion of α-catenin in limb mesenchyme had little effect on skeletal development.