کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10933384 | 1093794 | 2009 | 11 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Runx1 is involved in the fusion of the primary and the secondary palatal shelves
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کلمات کلیدی
Primary palateFGFTGFFGFRFGF18Runx1MEEmedial edge epithelium - اپیتلیوم لبه داخلیTem - این استtransforming growth factor - تبدیل فاکتور رشدEpithelial–mesenchymal interactions - تعاملات بین اپیتلیال و مزانشیمالSecondary palate - عادت دومfibroblast growth factor - فاکتور رشد فیبروبلاستcleft palate - لَبشِکَری یا لَبِ شکافته یا شکاف لبSEM - مدل معادلات ساختاری / میکروسکوپ الکترونی روبشیScanning electron microscopy - میکروسکوپ الکترونی روبشیTransmission electron microscopy - میکروسکوپ الکترونی عبوریPalatogenesis - پالاتوژنزfibroblast growth factor receptor - گیرنده فاکتور رشد فیبروبلاست
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
بیولوژی سلول
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Runx1 is involved in the fusion of the primary and the secondary palatal shelves Runx1 is involved in the fusion of the primary and the secondary palatal shelves](/preview/png/10933384.png)
چکیده انگلیسی
Runx1 is expressed in medial edge epithelial (MEE) cells of the palatal shelf. Conditionally rescued Runx1â/â mice showed limited clefting in the anterior junction between the primary and the secondary palatal shelves, but not in the junction between the secondary palates. In wild type mice, the fusing epithelial surface exhibited a rounded cobblestone-like appearance, while such cellular prominence was less evident in the Runx1 mutants. We also found that Fgf18 was expressed in the mesenchyme underlying the MEE and that locally applied FGF18 induced ectopic Runx1 expression in the epithelium of the palatal explants, indicating that Runx1 was induced by mesenchymal Fgf18 signaling. On the other hand, unpaired palatal explant cultures revealed the presence of anterior-posterior (A-P) differences in the MEE fates and fusion mechanism. Interestingly, the location of anterior clefting in Runx1 mutants corresponded to the region with different MEE behavior. These data showed a novel function of Runx1 in morphological changes in the MEE cells in palatal fusion, which is, at least in part, regulated by the mesenchymal Fgf signaling via an epithelial-mesenchymal interaction.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Developmental Biology - Volume 326, Issue 2, 15 February 2009, Pages 392-402
Journal: Developmental Biology - Volume 326, Issue 2, 15 February 2009, Pages 392-402
نویسندگان
Kesinee Charoenchaikorn, Tomomasa Yokomizo, David P. Rice, Tadashi Honjo, Kiyomi Matsuzaki, Yuko Shintaku, Yuichi Imai, Asami Wakamatsu, Satoru Takahashi, Yoshiaki Ito, Teruko Takano-Yamamoto, Irma Thesleff, Masayuki Yamamoto, Takashi Yamashiro,