کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10934004 | 1093876 | 2005 | 12 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Calcium signaling differentiation during Xenopus oocyte maturation
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کلمات کلیدی
EGTAd-myo-Inositol-1,4,5-trisphosphateCytoplasmic Ca2+Store operated Ca2+ entrySarco-endoplasmic reticulum Ca2+-ATPasePIP2GVBDSOCEMPFIP3IP3RPMCA1,2-bis(2-aminophenoxy)ethane-N,N,N′,N′-tetraacetic acid - 1،2-bis (2-aminophenoxy) ethane-N، N، N '، N'-tetraacetic acidEndocytosis - آندوسیتوز یا درون بریoocyte maturation - بلوغ تخمک یا بلوغ اووسیتBAPTA - بیایپیتیایgerminal vesicle breakdown - تجزیه غشایی ژرمینالCa2+ signaling - سیگنالینگ Ca2 +endoplasmic reticulum - شبکه آندوپلاسمی Plasma membrane Ca2+-ATPase - غشای پلاسما Ca2 + -ATPaseplasma membrane Ca2+ ATPase - غشای پلاسما Ca2 + ATPaseMaturation Promoting Factor - فاکتور ارتقا بلوغphosphatidylinositol-4,5-bisphosphate - فسفاتیدیلینستول-4،5-بیسفسفاتSERCA - قلبXenopus - قورباغه پنجه دارIP3 receptor - گیرنده IP3
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
بیولوژی سلول
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Calcium signaling differentiation during Xenopus oocyte maturation Calcium signaling differentiation during Xenopus oocyte maturation](/preview/png/10934004.png)
چکیده انگلیسی
Ca2+ is the universal signal for egg activation at fertilization in all sexually reproducing species. The Ca2+ signal at fertilization is necessary for egg activation and exhibits specialized spatial and temporal dynamics. Eggs acquire the ability to produce the fertilization-specific Ca2+ signal during oocyte maturation. However, the mechanisms regulating Ca2+ signaling differentiation during oocyte maturation remain largely unknown. At fertilization, Xenopus eggs produce a cytoplasmic Ca2+ (Ca2+cyt) rise that lasts for several minutes, and is required for egg activation. Here, we show that during oocyte maturation Ca2+ transport effectors are tightly modulated. The plasma membrane Ca2+ ATPase (PMCA) is completely internalized during maturation, and is therefore unable to extrude Ca2+ out of the cell. Furthermore, IP3-dependent Ca2+ release is required for the sustained Ca2+cyt rise in eggs, showing that Ca2+ that is pumped into the ER leaks back out through IP3 receptors. This apparent futile cycle allows eggs to maintain elevated cytoplasmic Ca2+ despite the limited available Ca2+ in intracellular stores. Therefore, Ca2+ signaling differentiates in a highly orchestrated fashion during Xenopus oocyte maturation endowing the egg with the capacity to produce a sustained Ca2+cyt transient at fertilization, which defines the egg's competence to activate and initiate embryonic development.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Developmental Biology - Volume 288, Issue 2, 15 December 2005, Pages 514-525
Journal: Developmental Biology - Volume 288, Issue 2, 15 December 2005, Pages 514-525
نویسندگان
Wassim El-Jouni, Byungwoo Jang, Shirley Haun, Khaled Machaca,