Keywords: فسفاتیدیلینستول-4،5-بیسفسفات; ALL; acute lymphoblastic leukemia; AML; acute myeloid leukemia; CLL; B-cell chronic lymphocytic leukemia; CML; chronic myelogenous leukemia; ERK; extracellular signal-regulated kinase; FN3; fibronectin type-III (domain); GBM; glioblastoma multiforme; JMML
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Intelligent substance delivery into cells using cell-penetrating peptides
Keywords: فسفاتیدیلینستول-4،5-بیسفسفات; CPP; cell-penetrating peptide; PTD; protein transduction domain; siRNA; small interfering ribonucleic acid; HIV-1; human immunodeficiency virus 1; Arg; arginine; Lys; lysine; Rn; polyarginine composed of n arginines, where n is natural number; a.a.; amino
Keywords: فسفاتیدیلینستول-4،5-بیسفسفات; EGFR; epidermal growth factor receptor; EGF; epidermal growth factor; MAP kinase; mitogen-activated protein kinase; PIP2; phosphatidylinositol-4,5-bisphosphate; Mut R1-6; EGFR mutant with six residues mutated to alanines in the juxtamembrane segment; PL
Organic matrices, ionic liquids, and organic matrices@nanoparticles assisted laser desorption/ionization mass spectrometry
Keywords: فسفاتیدیلینستول-4،5-بیسفسفات; Organic matrices; Nanoparticles; Ionic liquids; Matrix-assisted laser desorption/ionization mass spectrometry (MALDI-MS); Surface enhanced laser desorption/ionization mass spectrometry (SELDI-MS); 9-AA; 9-aminoacridine; APCI; atmospheric pressure chemical
Keywords: فسفاتیدیلینستول-4،5-بیسفسفات; MD; molecular dynamics; CG; coarse-grained; NMR; nuclear magnetic resonance; ESR; electron spin resonance; EM; electron microscopy; POPC; 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine; POPG; 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphoglycerol; POPE; 1-pa
Keywords: فسفاتیدیلینستول-4،5-بیسفسفات; ACSL1; long-chain acyl-CoA synthetase 1; ATGL; adipose triglyceride lipase; CerS5; ceramide synthase 5; CPT; carnitine palmitoyltransferase; DAG; diacylglycerol; DGAT; diacylglycerol acyltransferase; ER; endoplasmic reticulum; ERK; extracellular signal re
Keywords: فسفاتیدیلینستول-4،5-بیسفسفات; Phospholipid asymmetry; Lysophosphatidic; Platelet-activating factor; Phosphoinositides; PLRP2; Phospholipase B; 2-AG; 2-arachidonoyl-glycerol; ATX; autotaxin; cPLA2; cytosoluble phospholipase A2; DAG; diacylglycerol; ECs; endocannabinoids; IP3; inositol
Keywords: فسفاتیدیلینستول-4،5-بیسفسفات; Clathrin; Endocytosis; Endosome; Phosphatidylinositol-4,5-bisphosphate; Phosphatidylinositol-3,4-bisphosphate; CLIC/GEEC;
Keywords: فسفاتیدیلینستول-4،5-بیسفسفات; Lipid rafts; Signal transduction; IGF-I/PI3K/Akt signaling; Fas/CD95; CASMER; Cancer; APL; alkylphospholipid analogue; CASMER; cluster of apoptotic signaling molecule-enriched rafts; DED; death effector domain; DD; death domain; DISC; death-inducing signa
Keywords: فسفاتیدیلینستول-4،5-بیسفسفات; 2-AG; 2-arachidonoylglycerol; CDS; CDP-diacylglycerol synthase; CDP-DAG; CDP-diacylglycerol; DAG; diacylglycerol; DGK; diacylglycerol kinase; ER; endoplasmic reticulum; IP3; inositol triphosphate; LPA; lysophosphatidic acid; LPIAT1; lysophosphatidylinosit
Keywords: فسفاتیدیلینستول-4،5-بیسفسفات; Orexin; Hypocretin; Phospholipase; Endocannabinoid; Ion fluxes; 2-AG; 2-arachidonoylglycerol; AA; arachidonic acid; anandamide; N-arachidonoylethanolamine; CNS; central nervous system; cPLA2 and iPLA2; cytosolic (Ca2+-dependent) and intracellular (Ca2+-in
Keywords: فسفاتیدیلینستول-4،5-بیسفسفات; Phosphoinositide; Domain formation; Lipid phase behavior; Phosphatidylinositol; Cholesterol; Phosphatidylinositol-4,5-bisphosphate; PTEN
Keywords: فسفاتیدیلینستول-4،5-بیسفسفات; AP-1; adaptor protein 1; ASL; airway surface liquid; CCO; cytochrome c oxidase; CF; cystic fibrosis; COX-2; cyclooxygenase 2; Csk; c-src kinase; DMEM; Dulbeccos' minimal essential medium; DMT1; divalent metal ion transporter 1; DUOX; dual oxidase; EGFR;
Keywords: فسفاتیدیلینستول-4،5-بیسفسفات; CERT; ceramide transport protein; CPE; ceramide phosphoethanolamine; ER; endoplasmic reticulum; HDL; high density lipoprotein; LCAT; lecithin:cholesterol acyltransferase; LDL; low density lipoprotein; OSBP; oxysterol binding protein; PC; phosphatidylcholi
Transcriptional activation of a chimeric retrogene PIPSL in a hominoid ancestor
Keywords: فسفاتیدیلینستول-4،5-بیسفسفات; FBS; fetal bovine serum; PIP5K1A; phosphatidylinositol-4-phosphate 5-kinase, type I, alpha; PLCE1; phospholipase C epsilon 1; PP; processed pseudogene; PSMD4; proteasome 26S subunit, non-ATPase 4; PtdIns(4,5)P2; phosphatidylinositol-4,5-bisphosphate; RACE
Microfluidic device as a facile in vitro tool to generate and investigate lipid gradients
Keywords: فسفاتیدیلینستول-4،5-بیسفسفات; lipid gradient; Phosphoinositide; PI(4,5)P2; Phosphatidylinositol-4,5-bisphosphate; Phosphatidylserine; Domains;
Oncogenic mutations of PIK3CA and HRAS in carcinoma of cervix in South Indian women
Keywords: فسفاتیدیلینستول-4،5-بیسفسفات; Oncogenic mutations; Cervical cancer; Peripheral blood; PCR-CTPP method; PIK3CA; Phosphatidylinositol-4,5-Bisphosphate; 3-Kinase Catalytic Subunit Alpha; HRAS; Harvey rat sarcoma viral oncogene homolog; EGF; Epidermal Growth Factor; PDGF; Platelet Derived
Depsidone and xanthones from Garcinia xanthochymus with hypoglycemic activity and the mechanism of promoting glucose uptake in L6 myotubes
Keywords: فسفاتیدیلینستول-4،5-بیسفسفات; GLUT4; glucose transporter type 4; PI3K; phosphatidylinositol-3 kinase; PKB/Akt; serine/threonine kinase protein kinase B; AMPK; AMP-activated protein kinase; DM; diabetes mellitus; T2DM; type 2 diabetes mellitus; DMEM; Dulbecco's modified Eagle's med
ReviewRegulation of insulin exocytosis by calcium-dependent protein kinase C in beta cells
Keywords: فسفاتیدیلینستول-4،5-بیسفسفات; Protein kinase C; Insulin; Exocytosis; Beta cell; PKC; protein kinase C; DAG; diacylglycerol; PIP2; phosphatidylinositol-4,5-bisphosphate; GSIS; glucose stimulated insulin secretion; PLC; phospholipase C; IP3; inositol triphosphate; PMA; phorbol 12-myrist
ADP-ribosylation factor-like GTPase 15 enhances insulin-induced AKT phosphorylation in the IR/IRS1/AKT pathway by interacting with ASAP2 and regulating PDPK1 activity
Keywords: فسفاتیدیلینستول-4،5-بیسفسفات; ARL15; ASAP2; PDPK1; AKT; Insulin resistance; Phosphorylation; ARL15; ADP-ribosylation factor-like GTPase 15; ARF; ADP-ribosylation factor; ASAP2; ARF-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2; GEF; Guanine nucleotide-exchange fac
Phosphatidic acid induces EHD3-containing membrane tubulation and is required for receptor recycling
Keywords: فسفاتیدیلینستول-4،5-بیسفسفات; EHD3; Eps15 homology domain-containing protein 3; EE; early endosome; ERC; endocytic recycling compartment; PM; plasma membrane; DGK; diacylglycerol kinase; DAG; diacylglycerol; LPAAT; lysophosphatidic acid acyltransferase; LPA; lysophosphatidic acid; FIP
Biochemical characterization of the tomato phosphatidylinositol-specific phospholipase C (PI-PLC) family and its role in plant immunity
Keywords: فسفاتیدیلینستول-4،5-بیسفسفات; At; Arabidopsis thaliana; DAG; diacylglycerol; ETI; effector-triggered immunity; HR; hypersensitive response; InsP3; inositol 1,4,5-triphosphate; PA; phosphatidic acid; PAMPs; pathogen-associated molecular patterns; PI; phosphatidylinositol; PI-PLC; phosp
Membrane Interactions of the Mason-Pfizer Monkey Virus Matrix Protein and Its Budding Deficient Mutants
Keywords: فسفاتیدیلینستول-4،5-بیسفسفات; M-PMV; Mason-Pfizer monkey virus; MA; matrix protein; PI(4,5)P2; phosphatidylinositol-4,5-bisphosphate; PS; phosphatidylserine; PCH; phosphatidylcholine; diC8-PI(4,5)P2; dioctanoyl-PI(4,5)P2; WT; wild type; NOE; nuclear Overhauser effect; NOESY; NOE spect
Deficiency in the mRNA export mediator Gle1 impairs Schwann cell development in the zebrafish embryo
Keywords: فسفاتیدیلینستول-4،5-بیسفسفات; ALLn; anterior lateral line nerve; ALS; amyotrophic lateral sclerosis; CNS; central nervous system; Dbp5; DEAD box protein 5; EdU; 5-ethynyl-2â²-deoxyuridine; IP6; Inositol hexakisphosphate; LCCS1; lethal congenital contracture syndrome 1; mbp; myelin ba
Multifaceted plasma membrane Ca2Â + pumps: From structure to intracellular Ca2Â + handling and cancer
Keywords: فسفاتیدیلینستول-4،5-بیسفسفات; CaM; calmodulin; CBS; calmodulin-binding sequence; ER; endoplasmic reticulum; ERK; extracellular signal-regulated kinase; HDAC; histone deacetylase; HUVEC; human umbilical vein endothelial cells; IP3; inositol-1,4,5-trisphosphate; MLEC; mouse lung endothe
A structural insight into the inhibitory mechanism of an orally active PI3K/mTOR dual inhibitor, PKI-179 using computational approaches
Keywords: فسفاتیدیلینستول-4،5-بیسفسفات; PI3K; phosphatidylinositide 3-kinase; PIP2; phosphatidylinositol-4,5-bisphosphate; PIP3; phosphatidylinositol-3,4,5-trisphosphate; mTOR; mammalian target of rapamycin; mTORC1; mTOR complex 1; mTORC2; mTOR complex 2; ASA; accessible surface area; ÎASA; lo
Study of PTEN subcellular localization
Keywords: فسفاتیدیلینستول-4،5-بیسفسفات; AKAP; A kinase anchoring protein; ArA; arachidonic acid; Ca2+; calcium; CLS; cytoplasmic localization signal; Co-IP; co-immunoprecipitation; COX; cytochrome c oxidase; ER; endoplasmic reticulum; ER-RFP; endoplasmic reticulum-targeted red fluorescent prote
The C-terminal tail inhibitory phosphorylation sites of PTEN regulate its intrinsic catalytic activity and the kinetics of its binding to phosphatidylinositol-4,5-bisphosphate
Keywords: فسفاتیدیلینستول-4،5-بیسفسفات; PTEN; C-terminal tail; Phosphorylation; Phosphatase; Phosphatidylinositol-4,5-bisphosphate; Kinetics
MYC and metabolism on the path to cancer
Keywords: فسفاتیدیلینستول-4،5-بیسفسفات; 2-DG; 2-deoxyglucose; 4E-BP; eIF4E-binding protein; 5,10-methylene THF; 5,10-methylenetetrahydrofolate; ACC; acetyl-CoA carboxylase; ACLY; ATP-citrate lyase; AMPK; AMP-activated protein kinase; ATP; adenosine triphosphate; ChIP-seq; chromatin immunoprecip
Changing in lipid profile induced by the mutation of Foxn1 gene: A lipidomic analysis of Nude mice skin
Keywords: فسفاتیدیلینستول-4،5-بیسفسفات; Lipidomics; Lipids; Mass spectrometry; Skin; Foxn1; Cer; ceramide; CID; collision-induced dissociation; CV; coefficient of variation; CV-ANOVA; cross-validated analysis of variance; DG; diacylglycerol; DR; down-regulated; ECN; equivalent carbon number; ES
Calcium signaling in B cells: Regulation of cytosolic Ca2+ increase and its sensor molecules, STIM1 and STIM2
Keywords: فسفاتیدیلینستول-4،5-بیسفسفات; BCR; B cell receptor; CRAC; Ca2+-release activated Ca2+; PIP2; phosphatidylinositol-4,5-bisphosphate; IP3; inositol-1,4,5,-triphosphate; PIP3; phosphatidylinositol-3,4,5-trisphosphate; PLC-γ2; phospholipase-γ2; PI3K; phosphoinositide 3-kinase; EAE; expe
Activation of PI3K/Akt signaling in rostral ventrolateral medulla impairs brain stem cardiovascular regulation that underpins circulatory depression during mevinphos intoxication
Keywords: فسفاتیدیلینستول-4،5-بیسفسفات; aCSF; artificial cerebrospinal fluid; Akt; serine/threonine protein kinase; EMSA; electrophoretic mobility shift assay; HR; heart rate; LF; low-frequency; 3-MA; 3-methyladenine; NF-κB; nuclear factor-κB; NO; nitric oxide; NOS; nitric oxide synthase; NRS
Signaling through C2 domains: More than one lipid target
Keywords: فسفاتیدیلینستول-4،5-بیسفسفات; C2 domain; Phosphatidylinositol-4,5-bisphosphate; Ca2Â +-signaling protein; Signaling domain;
Plant phosphoinositide-dependent phospholipases C: Variations around a canonical theme
Keywords: فسفاتیدیلینستول-4،5-بیسفسفات; Phospholipase C; Lipid signalling; Phosphoinositides; Inositol-phosphate; Phosphatidic acid; ABA; abscisic acid; DAG; diacylglycerol; DGK; DAG-kinase; IP3; inositol triphosphate; IP5; inositol pentakisphosphate; IP6; inositol hexakisphosphate; PA; phospha
A century old renin-angiotensin system still grows with endless possibilities: AT1 receptor signaling cascades in cardiovascular physiopathology
Keywords: فسفاتیدیلینستول-4،5-بیسفسفات; RAS; renin-angiotensin system; AOG; angiotensinogen; Ang II; angiotensin II; ACE; angiotensin converting enzyme; ARBs; angiotensin AT1 receptor blockers; Mas R; Mas receptor; TGF-β; transforming growth factor-β; Ang A; angiotensin A; eNOS; endothelial
Impaired Na+-dependent regulation of acetylcholine-activated inward-rectifier K+ current modulates action potential rate dependence in patients with chronic atrial fibrillation
Keywords: فسفاتیدیلینستول-4،5-بیسفسفات; AF; atrial fibrillation; AP; action potential; APD; AP duration; cAF; chronic AF; CCh; carbachol; ICa,L; L-type Ca2Â + current; IK1; basal inward-rectifier K+ current; IK,ACh; muscarinic-receptor-activated K+ current; INaK; Na+-K+ ATPase current; [Na+]i;
Lipid organization regulates annexin A2 Ca2Â +-sensitivity for membrane bridging and its modulator effects on membrane fluidity
Keywords: فسفاتیدیلینستول-4،5-بیسفسفات; Anx; Annexin; DRM; detergent-resistant membranes; LUV; large unilamellar vesicles; MDCK; Madin Darby canine kidney; PE; phosphatidylethanolamine; PI2P; phosphatidylinositol-4,5-bisphosphate; PS; phosphatidylserine; Anionic phospholipid; Annexin A2; Calciu
cAMP: Novel concepts in compartmentalised signalling
Keywords: فسفاتیدیلینستول-4،5-بیسفسفات; cAMP; cyclic adenosine 3â²,5â²-monophosphate; GPCR; G protein-coupled receptor; EC coupling; excitation-contraction coupling; FRET; Förster/fluorescence resonance energy transfer; CFP; cyan fluorescent protein; YFP; yellow fluorescent protein; AKAR;
An anti-phosphoinositide-specific monoclonal antibody that neutralizes HIV-1 infection of human monocyte-derived macrophages
Keywords: فسفاتیدیلینستول-4،5-بیسفسفات; Ab; Antibody; GalCer; Galactosyl ceramide; HIV-1; Human immunodeficiency virus type 1; M-CSF; Macrophage colony stimulating factor; MPER; Membrane proximal external region; mAb; Monoclonal antibody; MDM; Monocyte-derived macrophages; PBMCs; Peripheral blo
Phospholipases C and sphingomyelinases: Lipids as substrates and modulators of enzyme activity
Keywords: فسفاتیدیلینستول-4،5-بیسفسفات; Phospholipase C; Sphingomyelinase; Lipid-protein interactions; Enzyme regulation; Vesicle aggregation; Vesicle fusion; aSMase; acid sphingomyelinase; Cer; ceramide; Chol; cholesterol; DAG; diacylglyceride; DPPC; dipalmitoyl phosphatidylcholine; FRET; fl
Stimuli-triggered structural engineering of synthetic and biological polymeric assemblies
Keywords: فسفاتیدیلینستول-4،5-بیسفسفات; AFM; atomic force microscopy; ATP; adenosine triphosphate; CPB; polybutadiene with a terminal carboxyl group; 3D; three-dimensional; DAP; diamidopyridine; DETA; diethylenetriamine; DEX; dexamethasone; DIC; differential interference contrast; DLS; dynamic
The transphosphatidylation potential of a membrane-bound phospholipase D from poppy seedlings
Keywords: فسفاتیدیلینستول-4،5-بیسفسفات; Phospholipase D; Membrane-bound enzyme; Papaver somniferum; Transphosphatidylation; Phosphatidylinositol-4,5-bisphosphate; Calcium; Immunochemical analysis;
Influence of liposome composition and membrane binding on protein kinase activity of PI3Kγ
Keywords: فسفاتیدیلینستول-4،5-بیسفسفات; catD; catalytic domain; WT; wildtype; PI; phosphatidylinositol; PI-4-P; phosphatidylinositol-4-phosphate; PI-45-P2; phosphatidylinositol-4,5-bisphosphate; PC; phosphatidylcholine; PE; phosphatidylethanolamine; Rh-PE; rhodamine-PE; PS; phosphatidylserine;
Targeting PI3K Signaling as a Therapeutic Approach for Colorectal Cancer
Keywords: فسفاتیدیلینستول-4،5-بیسفسفات; Colon Cancer; Neoplasm; Signal Transduction; Genetics; Tumor; CRC; colorectal cancer; EGF; epidermal growth factor; EGFR; epidermal growth factor receptor; GPCR; G-protein-coupled receptor; IRS1; insulin receptor substrate 1; MEF; murine embryonic fibro
Signal-transduction networks and the regulation of muscle protein degradation
Keywords: فسفاتیدیلینستول-4،5-بیسفسفات; 15(S)-HETE; 15(S)-hydroxyeicosatetraenoic acid; ACh; acetylcholine; Akt; protein kinase B; CNTF; ciliary neurotrophic factor; EGF; epidermal growth factor; FGF; fibroblast growth factor; FOXO; forkhead transcription factor; Grb2; growth factor receptor bo
Phospholipase D from Allium sativum bulbs: A highly active and thermal stable enzyme
Keywords: فسفاتیدیلینستول-4،5-بیسفسفات; BCA; bicinchoninic acid; GDH; glutamate dehydrogenase; PC; phosphatidylcholine; PE; phosphatidylethanol; PIP2; phosphatidylinositol-4,5-bisphosphate; PLD; phospholipase D; PLDCL; PLD from cabbage leaves; PLDGB; PLD from garlic bulbs; Phospholipase D; Alli
Complex regulation of the TRPC3, 6 and 7 channel subfamily by diacylglycerol and phosphatidylinositol-4,5-bisphosphate
Keywords: فسفاتیدیلینستول-4،5-بیسفسفات; Calcium channels; Ion channels; TRP channels; TRPC7; Phosphatidylinositol-4,5-bisphosphate; Diacylglycerols; Patch-clamp;
Calmodulin potentiates Gβγ activation of phospholipase C-β3
Keywords: فسفاتیدیلینستول-4،5-بیسفسفات; PLC; phosphatidylinositol phospholipid-specific phospholipase C; PE; phosphatidylethanolamine; PS; phosphatidylserine; PIP 16:0; synthetic phosphatidylinositol-4-phosphate with symmetric 16:0 saturated fatty acyl chains; PIP; phosphatidylinositol-4-phosph
A role for diacylglycerol in annexin A7-mediated fusion of lung lamellar bodies
Keywords: فسفاتیدیلینستول-4،5-بیسفسفات; DAG; diacylglycerol; DPE; dansyl phosphatidylethanolamine; F345; fluorescence at 345Â nm; PC; phosphatidylcholine; PE; phosphatidylethanolamine; PIP2; phosphatidylinositol-4,5-bisphosphate; PI; phosphatidylinositol; PS; phosphatidylserine; PKC; protein ki
Opposing effects of Bad phosphorylation at two distinct sites by Akt1 and JNK1/2 on ischemic brain injury
Keywords: فسفاتیدیلینستول-4،5-بیسفسفات; Bad phosphorylation; JNK; Akt; SP600125; bpV(pic); Cerebral ischemia; JNK; c-Jun N-terminal kinase; MAPK; mitogen-activated protein kinase; PI3K; phosphoinositide 3-kinase; ERK; Extracellular signal regulated kinase; PKA; protein kinase A; RTK; receptor t