کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10842900 | 1068556 | 2013 | 14 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Biological functions of sphingomyelins
ترجمه فارسی عنوان
عملکرد بیولوژیکی اسپینگومایین
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کلمات کلیدی
TransferrinCeramide phosphoethanolamineSMSRPIP2LCATAtherogenesisCERTOSBPTMDSMaseSPTHDLCPESACToxin binding - اتصال سم زداییsphingomyelin - اسفنگومیلینsphingomyelin synthase - اسپینگومایین سنتازsphingomyelinase - اسپینگومایینازtransmembrane domain - دامنه فرابنفشserine palmitoyl transferase - سرمین پالمیتویل ترانسفرازendoplasmic reticulum - شبکه آندوپلاسمی phosphatidylcholine - فسفاتیدیل کولینphosphatidylinositol-4,5-bisphosphate - فسفاتیدیلینستول-4،5-بیسفسفاتLecithin:cholesterol acyltransferase - لسیتین: آستیلترانسفراز کلسترولhigh density lipoprotein - لیپوپروتئین با چگالی بالاlow density lipoprotein - لیپوپروتئین چگالی کمLDL - لیپوپروتئین کم چگالی(کلسترول بد)Microdomains - میکرو دومی هاoxysterol binding protein - پروتئین اتصال اکسسترینceramide transport protein - پروتئین حمل و نقل سرامیدSMS - پیامکMolecular species - گونه های مولکولی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم کشاورزی و بیولوژیک
دانش تغذیه
چکیده انگلیسی
Sphingomyelin (SM) is a dominant sphingolipid in membranes of mammalian cells and this lipid class is specifically enriched in the plasma membrane, the endocytic recycling compartment, and the trans Golgi network. The distribution of SM and cholesterol among cellular compartments correlate. Sphingolipids have extensive hydrogen-bonding capabilities which together with their saturated nature facilitate the formation of sphingolipid and SM-enriched lateral domains in membranes. Cholesterol prefers to interact with SMs and this interaction has many important functional consequences. In this review, the synthesis, regulation, and intracellular distribution of SMs are discussed. The many direct roles played by membrane SM in various cellular functions and processes will also be discussed. These include involvement in the regulation of endocytosis and receptor-mediated ligand uptake, in ion channel and G-protein coupled receptor function, in protein sorting, and functioning as receptor molecules for various bacterial toxins, and for non-bacterial pore-forming toxins. SM is also an important constituent of the eye lens membrane, and is believed to participate in the regulation of various nuclear functions. SM is an independent risk factor in the development of cardiovascular disease, and new studies have shed light on possible mechanism behind its role in atherogenesis.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Progress in Lipid Research - Volume 52, Issue 4, October 2013, Pages 424-437
Journal: Progress in Lipid Research - Volume 52, Issue 4, October 2013, Pages 424-437
نویسندگان
J. Peter Slotte,