کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8305983 | 1538434 | 2014 | 14 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Plant phosphoinositide-dependent phospholipases C: Variations around a canonical theme
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کلمات کلیدی
ABAInositol-phosphateinositol pentakisphosphatePhosphatidylinositol-4-phosphateIP5PI-PLCDGKinositol triphosphateIP3IP6PLDSUMOInositol hexakisphosphate - Inositol hexakis فسفاتabscisic acid - اسید آبسزیکSalicylic acid - اسید سالیسیلیکphosphatidic acid - اسید فسفاتیدیکdiacylglycerol - دیسیل گلیسیرینDAG - روزLipid signalling - سیگنالینگ لیپیدphosphatidylinositol - فسفاتیدیل اینوزیتولphosphatidylinositol-4,5-bisphosphate - فسفاتیدیلینستول-4،5-بیسفسفاتPhosphoinositides - فسفوئینوزیت هاphospholipase C - فسفولیپاز CPhospholipase D - فسفولیپاز DPleckstrin Homology - همخوانی Pleckstrinsmall ubiquitin-like modifier - کوچک مانند ubiquitin مانند اصلاح کننده
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
پیش نمایش صفحه اول مقاله
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چکیده انگلیسی
Phosphoinositide-specific phospholipase C (PI-PLC) cleaves, in a Ca2+-dependent manner, phosphatidylinositol-4,5-bisphosphate (PI-4,5-P2) into diacylglycerol (DAG) and inositol triphosphate (IP3). PI-PLCs are multidomain proteins that are structurally related to the PI-PLCζs, the simplest animal PI-PLCs. Like these animal counterparts, they are only composed of EF-hand, X/Y and C2 domains. However, plant PI-PLCs do not have a conventional EF-hand domain since they are often truncated, while some PI-PLCs have no EF-hand domain at all. Despite this simple structure, plant PI-PLCs are involved in many essential plant processes, either associated with development or in response to environmental stresses. The action of PI-PLCs relies on the mediators they produce. In plants, IP3 does not seem to be the sole active soluble molecule. Inositol pentakisphosphate (IP5) and inositol hexakisphosphate (IP6) also transmit signals, thus highlighting the importance of coupling PI-PLC action with inositol-phosphate kinases and phosphatases. PI-PLCs also produce a lipid molecule, but plant PI-PLC pathways show a peculiarity in that the active lipid does not appear to be DAG but its phosphorylated form, phosphatidic acid (PA). Besides, PI-PLCs can also act by altering their substrate levels. Taken together, plant PI-PLCs show functional differences when compared to their animal counterparts. However, they act on similar general signalling pathways including calcium homeostasis and cell phosphoproteome. Several important questions remain unanswered. The cross-talk between the soluble and lipid mediators generated by plant PI-PLCs is not understood and how the coupling between PI-PLCs and inositol-kinases or DAG-kinases is carried out remains to be established.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochimie - Volume 96, January 2014, Pages 144-157
Journal: Biochimie - Volume 96, January 2014, Pages 144-157
نویسندگان
Igor Pokotylo, Yaroslav Kolesnikov, Volodymyr Kravets, Alain Zachowski, Eric Ruelland,