Keywords: AFM; (mixed) amplitude and frequency modulation; AM; amplitude modulation; AMPA; α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid; ATP; adenosine triphosphate; BC; basket cell; ER; endoplasmic reticulum; FM; frequency modulation; GABA; γ-aminobutyri
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Keywords: ADP; adenosine 5â²-diphisphate; COX; cyclooxygenase; CYP; cytochromes P450; GP; glycoprotein; IP3; inositol triphosphate; PFA-100; platelet function analyzer; PSGL-1; P-selectin glycoprotein ligand-1; sCD40L; subule CD40 ligand; TXA2; thromboxane A2; vWF
Keywords: ATP; adenosine triphosphate; Ca2+; Â calcium; CamK; calmodulin-dependent kinase; ChREBP; carbohydrate response element binding protein; CypD; cylophilin D; DGAT2; diacylglycerol acyltransferase 2; ER; endoplasmic reticulum; FOXO1; Forkhead box O1; G6P; gl
Keywords: 2-APB; 2-aminoethoxydiphenyl borate;; ATP; adenosine triphosphate; CT; C-terminal tail; Cx(s); connexin(s); dsRNA; double-stranded RNA; EL(s); extracellular loop(s); GA; glycyrrhetinic acid; GABA; γ-amino butyric acid; GJ(s); gap junction(s); GJIC; gap j
Keywords: (I-R); ischemia-reperfusion injury; IPC; ischemia preconditioning; ROS; reactive oxygen species; RNS; reactive nitrogen species; (ONOOâ); peroxynitrite; PI3K; phosphatidylinositol 3-kinase; PIP3; phosphatidyl-inositol 3,4,5-triphosphate; PIP2; phosp
Keywords: ADMA; asymmetric dimethylarginine; cAMP; cyclic adenosine monophosphate; CD73; cluster of differentiation 73; CDC2; cell division cycle 2; CFTR; cystic fibrosis transmembrane conductance regulator; cGMP; cyclic guanosine monophosphate; CH; chronic hypoxia
Keywords: ARDS; acute respiratory distress syndrome; AHR; airway hyperresponsiveness; ASM; airway smooth muscle; BAL; bronchoalveolar lavage; CPA; carboxypeptidase A; CADM1; cell adhesion molecule 1; COPD; chronic obstructive pulmonary disease; NADPH; dihydronicoti
Keywords: 2-AG; 2-arachidonoylglycerol; CDS; CDP-diacylglycerol synthase; CDP-DAG; CDP-diacylglycerol; DAG; diacylglycerol; DGK; diacylglycerol kinase; ER; endoplasmic reticulum; IP3; inositol triphosphate; LPA; lysophosphatidic acid; LPIAT1; lysophosphatidylinosit
Keywords: Cx; connexin; HPV; human papilloma virus; NSHI; non-syndromic hearing impairment; ODDD; oculodentodigital dysplasia; ZO-1; zona occludens 1; E1 and E2; extracellular domains 1 and 2; PPK; palmoplantar hyperkeratinisation; KID; keratitis ichthyosis deafn
Apelin, a promising target for Alzheimer disease prevention and treatment
Keywords: Alzheimer disease; Apelin; Amyloid beta; Central nervous system; Oxidative stress; AAA; Abdominal aortic aneurysm; ABCA1; ATP-binding cassette transporter A1; ACE; Angiotensin converting enzyme; ACh; Acetylcholine; AChE; Acetyl choline esterase; AD; Alzhe
The natural sesquiterpene lactones arglabin, grosheimin, agracin, parthenolide, and estafiatin inhibit T cell receptor (TCR) activation
Keywords: Sesquiterpene lactones; Jurkat T cells; T cell receptor; Kinase; Phosphorylation; Calcium flux; Glutathione; DMSO; dimethyl sulfoxide; FBS; fetal bovine serum; FPR; N-formyl peptide receptor; HBSS; Hanks' balanced salt solution; IP3; inositol triphosphate
Selectively targeting prostanoid E (EP) receptor-mediated cell signalling pathways: Implications for lung health and disease
Keywords: ASM; airway smooth muscle; BAL; bronchoalveolar; CHO; Chinese hamster ovary; COX; cyclooxygenase; EP; prostanoid E; ERK; extracellular signal-regulated kinase; GPCR; G protein-coupled receptors; GSK-3; glucogen synthase kinase-3; HMLC; human lung mast cel
Inhibition of cytokine-mediated JNK signalling by purinergic P2Y11 receptors, a novel protective mechanism in endothelial cells
Keywords: G-protein coupled receptors; Interleukin-1β; C-Jun N-terminal kinase; Purinergic receptors; Inflammation; YM-254890 (PubChem CID: 9919454); H-89 (PubChem CID: 449241); NF340 (PubChem CID: 73755007); MRS2179 (PubChem CID: 24867852); ZM241385 (PubChem CID:
Development of potent and proteolytically stable human neuromedin U receptor agonists
Keywords: Neuromedin U (NMU); NMU-8; Neuromedin U receptor agonists; Plasma stability; 1â²Nal; 1â²-naphtylalanine; 2â²Nal; 2â²-naphtylalanine; 7-OH-Tic; 7-hydroxy-L-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid; ACN; acetonitrile; AUC; area under the curve;
The G protein-coupled receptors deorphanization landscape
Keywords: GPCRs; G protein-coupled receptors; GRK; GPCR kinase; IUPHAR; International Union of Basic and Clinical Pharmacology; BPS; British Pharmacological Society; CTR; Calcitonin receptor; CLR; CT Receptor-like; RAMP; Receptor Activity-Modifying Proteins; β2AR;
Acetylcholine-induced ex vivo ATP release from the human nasal mucosa
Keywords: Ach; acetylcholine; M3AchR; M3 acetylcholine receptor; PLC; phospholipase C; PIP2; phosphatidylinositol bisphosphate; DAG; diacylglycerol; IP3; inositol triphosphate; IP3R; inositol triphosphate receptor; P2X7; purinergic P2X7 receptor; Human nasal mucosa
ReviewRegulation of insulin exocytosis by calcium-dependent protein kinase C in beta cells
Keywords: Protein kinase C; Insulin; Exocytosis; Beta cell; PKC; protein kinase C; DAG; diacylglycerol; PIP2; phosphatidylinositol-4,5-bisphosphate; GSIS; glucose stimulated insulin secretion; PLC; phospholipase C; IP3; inositol triphosphate; PMA; phorbol 12-myrist
Ugonin U stimulates NLRP3 inflammasome activation and enhances inflammasome-mediated pathogen clearance
Keywords: ASC; apoptosis-associated speck-like protein containing a caspase recruitment domain; [Ca2+]i; intracellular calcium concentration; DAMPs; danger-associated molecular patterns; IP3; inositol triphosphate; IP3R; inositol triphosphate receptor; LPS; lipopol
Profiling conserved biological pathways in Autosomal Dominant Polycystic Kidney Disorder (ADPKD) to elucidate key transcriptomic alterations regulating cystogenesis: A cross-species meta-analysis approach
Keywords: ADPKD; Autosomal Dominant Polycystic Kidney disease; GEO; Gene Expression Omnibus; PC1; polycystin-1; PC2; polycystin-2; DEGs; differentially expressed genes; BH; Benjamini & Hochberg; GO; Gene Ontology; GO BP; GO Biological Processes; PANTHER; Protein AN
Bothriurus bonariensis scorpion venom activates voltage-dependent sodium channels in insect and mammalian nervous systems
Keywords: Arthropods; Poison; Neurotoxicity; Neuromuscular blockade; Calcium influx; BBV; Bothirurus bonariensis venom; 4-AP; 4-aminopyridine; TTX; tetrodotoxin citrate; DIV; days in vitro; HBS; HEPES-buffered saline; GLU; glutamate; SNCAP; spontaneous neural comp
Non-genomic oestrogen receptor signal in B lymphocytes: An approach towards therapeutic interventions for infection, autoimmunity and cancer
Keywords: mER; membrane bound oestrogen receptor; GPER; G-protein coupled oestrogen receptor; PIP2; phosphatidylinositol 4,5-biphosphate; IP3; inositol triphosphate; PI3 kinase; phosphoinositide 3-kinase; Akt; protein kinase B a Serine/Threonine specific protein ki
Immunoreceptors on neutrophils
Keywords: ADCC; antibody-dependent cellular cytotoxicity; ANCAs; anti-neutrophil autoantibodies; Btk; Bruton's tyrosine kinase; DAG; diacyl-glycerol; DAP12; DNAX activation protein of 12Â kDa; ERK; extracellular signal-regulated kinase; fMLP; N-Formylmethionine-leu
Calcium regulation of HCN channels supports persistent activity in a multiscale model of neocortex
Keywords: Ca2+; calcium; E cell; excitatory cell; E2/3 or E2; excitatory cell of layer 2/3, similarly E5, E6; E/I balance; excitation/inhibition balance; ER; endoplasmic reticulum; FRD; firing-rate distinction; FS cell; fast-spiking soma-targeting interneuron; HCN
Prevalence and audiological profiles of GJB2 mutations in a large collective of hearing impaired patients
Keywords: GJB2; Connexin 26; Genetics; Non-syndromic; Gap junctions; Hearing loss; ABI; auditory brainstem implant; CI; cochlear implant; Click-ABR; click auditory brainstem response; ECochG; electrocochleography; IHC; inner hair cells; IP3; inositol triphosphate;
Effects of ouabain on respiratory rhythm generation in brainstem-spinal cord preparation from newborn rats and in decerebrate and arterially perfused in situ preparation from juvenile rats
Keywords: ACSF; artificial cerebrospinal fluid; C4; fourth cervical ventral root; EGTA; ethylene glycol tetraacetic acid; HEPES; 4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid; IP3; inositol triphosphate; PBS; phosphate-buffered solution; pFRG; parafacial respi
Des-aspartate angiotensin I (DAA-I) reduces endothelial dysfunction in the aorta of the spontaneously hypertensive rat through inhibition of angiotensin II-induced oxidative stress
Keywords: ACE; angiotensin converting enzyme; AT1R; angiotensin II type 1 receptor; AT2R; angiotensin II type 2 receptor; cGMP; cyclic guanosine monophosphate; DAA-I; Des- aspartate angiotensin I; DAG; diacylgylcerol; EDCF; endothelium-derived contracting factor; E
Lipid agonism: The PIP2 paradigm of ligand-gated ion channels
Keywords: AA; arachidonic acid; ASIC; acid-sensing ion channel; ATP; adenosine triphosphate; BK; big conductance potassium channel; Cav; voltage-dependent calcium channel or VDCC; Ci-VSP; Ciona intestinalis voltage-sensitive phosphatase; CoA; coenzyme A; CTD; cytop
Fine-tuned ATP signals are acute mediators in osteocyte mechanotransduction
Keywords: 2-meSATP; 2-methyl-thio-ATP,; ATPγS; adenosine 5â²-[γ-thio]-triphosphate;  ÷ BIC; HCO3â-free buffer; BzATP; 2´,3´-O-benzoylbenzoyl-ATP; [Ca2 +]i; intracellular calcium concentration; CBX; carbenoxolone; Cx43; connexin 43; IP3; inositol triphosp
The anti-inflammatory effect of 2-(4-hydroxy-3-prop-2-enyl-phenyl)-4-prop-2-enyl-phenol by targeting Lyn kinase in human neutrophils
Keywords: BSA; bovine serum albumin; cAMP; cyclic AMP; DPI; diphenyliodonium; ELISA; enzyme-linked immune-sorbent assay; ERK; extracellular signal-regulated kinase; FLPEP; N-formyl-nor-leucyl-leucyl-phenylalanyl-norleucyl-throsyl-lysine-fluorescein; fMLP; N-formyl-
Pathophysiology of the hepoxilins
Keywords: AA; arachidonic acid; AMG9810; (2E)-N-(2,3-dihydro-1,4-benzodioxin-6-yl)-3-[4-(1,1-dimethylethyl)phenyl]-2-propenamide; Apaf-1; Apoptotic protease activating factor 1; BAPTA; 1,2-Bis(o-aminophenoxy)ethane-N,N,Nâ²,Nâ²-tetraacetic acid; CCCP; carbonyl cya
Downregulation of kinin B1 receptor function by B2 receptor heterodimerization and signaling
Keywords: kB1R; kinin B1 receptor; kB2R; bradykinin B2 receptor; GPCR; G protein-coupled receptor; BK; bradykinin; KD; kallidin; DABK; des-Arg9-bradykinin; DAKD; des-Arg10-kallidin; LV; left ventricular; ACE; angiotensin I converting enzyme; DMEM; Dulbecco's Modifi
Astrogliosis as a therapeutic target for neurodegenerative diseases
Keywords: AD; Alzheimer's disease; ALS; amyotrophic lateral sclerosis; ATP; adenosine triphosphate; BB14®; nerve growth factor-like peptide; BDNF; brain-derived neurotrophic factor; Ca2+; calcium; CNS; central nervous system; COX-1/2; cyclooxygenase-1/2; EAAC1; ex
Inhibition of protein kinase C (PKC) response of voltage-gated calcium (Cav)2.2 channels expressed in Xenopus oocytes by Cavβ subunits
Keywords: Ala; alanine; Asp; aspartate; BID; β interaction domain; Cav; high voltage-gated calcium channels; [Ca2+]i; intracellular Ca2+; Hepes; 4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid; IBa; basal barium current; IP3; inositol triphosphate; MAGUK; membr
Genotype-specific alterations in vascular smooth muscle cell function in cystic fibrosis piglets
Keywords: CF; cystic fibrosis; CFTR; cystic fibrosis transmembrane conductance regulator; dF; CFTR-F508del; ER; endoplasmic reticulum; IP3; inositol triphosphate; PSS; physiologic saline solution; VSMC; vascular smooth muscle cell; WT; wild-type.; Cystic fibrosis t
Pharmacological characterization and chemical fractionation of a liposterolic extract of saw palmetto (Serenoa repens): Effects on rat prostate contractility
Keywords: ATP; adenosine-5'-triphosphate disodium salt; 2-APB; 2-aminoethoxydiphenyl borate; BPH; benign prostatic hyperplasia; ESI/APCI; electrospray ionization/atmospheric pressure chemical ionization; IP3; inositol triphosphate; MS; mass spectrometry; PDA; phorb
A novel immunomodulatory effect of ugonin U in human neutrophils via stimulation of phospholipase C
Keywords: [Ca2+]i; intracellular calcium concentration; EB; ethidium bromide; ER; endoplasmic reticulum; fMLF; N-formylmethionyl-leucyl-phenylalanine; FNLFNYK; N-formyl-Nle-Leu-Phe-Nle-Tyr-Lys-fluorescein; FPR1; formyl peptide receptor 1; HE; hydroethidine; IP3; in
Annexins - Scaffolds modulating PKC localization and signaling
Keywords: AKAP; A-kinase-anchoring protein; Anx; annexin; Ca2Â +; calcium; DAG; diacylglycerol; EGFR; epidermal growth factor receptor; HSP; heat shock protein; IP3; inositol triphosphate; MAPK; mitogen-activated protein kinase; PI(4,5)P2; phosphoinositide 4,5-biph
Plant phosphoinositide-dependent phospholipases C: Variations around a canonical theme
Keywords: Phospholipase C; Lipid signalling; Phosphoinositides; Inositol-phosphate; Phosphatidic acid; ABA; abscisic acid; DAG; diacylglycerol; DGK; DAG-kinase; IP3; inositol triphosphate; IP5; inositol pentakisphosphate; IP6; inositol hexakisphosphate; PA; phospha
Receptor-mediated Ca2Â + and PKC signaling triggers the loss of cortical PKA compartmentalization through the redistribution of gravin
Keywords: AKAP; A-Kinase Anchoring Protein; ATP; adenosine triphosphate; β2AR; β2-adrenergic receptor; BAPTA-AM; 1,2-Bis(2-aminophenoxy)ethane-N,N,Nâ²,Nâ²-tetraacetic acid tetrakis(acetoxymethyl ester); BIM; bisindolylmaleimide; [Ca2 +]i; intracellular calcium
Characterization of dual agonists for kinin B1 and B2 receptors and their biased activation of B2 receptors
Keywords: CP; carboxypeptidase; kB1R; kinin B1 receptor; kB2R; bradykinin B2 receptor; [Ca2Â +]i; intracellular calcium concentration; PBS; phosphate buffered saline; DMEM; Dulbecco's Modified Eagle's Medium; GPCR; G protein-coupled receptor; BK; bradykinin; KD; ka
Visualization and quantification of endoplasmic reticulum Ca2+ in renal cells using confocal microscopy and Fluo5F
Keywords: ER; endoplasmic reticulum; EGTA; ethylene glycol tetraacetic acid; RPTC; renal proximal tubular cell; TMRM; tetramethyl rhodamine methyl ester; Fluo5F; Fluo-5F-AM; LSCM; laser scanning confocal microscopy; FCCP; carbonylcyanide-p-trifluoromethoxyphenylhyd
Norcantharidin induces cell cycle arrest and inhibits progression of human leukemic Jurkat T cells through mitogen-activated protein kinase-mediated regulation of interleukin-2 production
Keywords: AP-1; activating protein-1; CaN; calcineurin; CsA; Cyclosporine A; CyP; cyclophilin; ERK; extracellular signal-regulated protein kinase; FCS; fetal calf serum; FK506; Tacrolimus; IP3; inositol triphosphate; JNK; c-Jun NH2-terminal kinases; MAPK; mitogen-a
Extracellular Ca2+ entry and mobilization of inositol trisphosphate-dependent Ca2+ stores modulate histamine and electrical field stimulation induced contractions of the guinea-pig prostate
Keywords: Inositol triphosphate; Smooth muscle; Electrical field stimulation; Histamine; Prostate;
Analysis of expression and structure of the rat GH-secretagogue/ghrelin receptor (Ghsr) gene: Roles of epigenetic modifications in transcriptional regulation
Keywords: 5-aza-dC; 5-aza-2-deoxycytidine; ChIP; chromatin immunoprecipitation; ERK1/2; extracellular signal-regulated kinase 1/2; DMEM; Dulbecco's modified Eagle's medium; DNMT; DNA methyltransferase; EST; expressed sequence tag; FBS; fetal bovine serum; GH; g
Mimicking nature's noses: From receptor deorphaning to olfactory biosensing
Keywords: BAW; bulk acoustic wave; BRET; bioluminescence resonance energy transfer; cVA; 11-cis-vaccenyl acetate; cAMP; cyclic adenosine monophosphate; cGMP; cyclic guanosine monophosphate; CNG; cyclic nucleotide gated; EAG; electroantennagram; EOG; electroolfactog
PAC1hop receptor activation facilitates catecholamine secretion selectively through 2-APB-sensitive Ca2+ channels in PC12 cells
Keywords: AC; Adenylate cyclase; BCCs; Bovine chromaffin cells; Ca2+; Calcium; [Ca2+]i; Cytosolic calcium concentration; cAMP; Cyclic adenosine monophosphate; DMEM; Dulbecco's Modification of Eagle's Medium; ER; Endoplasmic reticulum; GPCR; G-protein coupled recept
Gap junctional intercellular communication in hypoxia-ischemia-induced neuronal injury
Keywords: AGA; 18α-glycyrrhetinic acid; AMPA; alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid; ATP; adenosine triphosphate; cAMP; cyclic adenosine monophosphate; CNS; central nervous system; Cx; connexin; FRIL; freeze-fracture replica immunogold labeling
The nerve growth factor and its receptors in airway inflammatory diseases
Keywords: ADAM; a disintegrin and metalloprotease domain; AP-1; activating protein 1; AP-2; clathrin adaptative protein-2; APPL; amyloid precursor protein-like; ARMS; ankyrin repeat-rich membrane spanning; BDNF; brain-derived neurotrophic factor; bFGF; basic fibrob
Effects of carbonic anhydrase VIII deficiency on cerebellar gene expression profiles in the wdl mouse
Keywords: Carbonic anhydrase VIII; Dystonia; Ataxia; Cerebellum; Calcium signaling; Inositol triphosphate
Participation of the inositol phospholipid signaling pathway in the increase in cytosolic calcium induced by tributyltin chloride intoxication of chlorophyllous protozoa Euglena gracilis Z and its achlorophyllous mutant SM-ZK
Keywords: Euglena gracilis; Intracellular Ca2+; Inositol triphosphate; Mastoparan; Morphological alteration; Neomycin; Signal transduction; Tributyltin;